ML domain

ML domain

X-ray structure of Der p 2, the major house dust mite allergen
Identifiers
Symbol E1_DerP2_DerF2
Pfam PF02221
InterPro IPR003172
SCOP 1a9v
SUPERFAMILY 1a9v
OPM protein 1nep
CDD cd00912

The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like beta-sandwich fold similar to that of immunoglobulin E-set domains. This domain is present in the following proteins:

Human proteins containing this domain

LY86; LY96; MMD-1;

References

  1. Lobel P, Stock AM, Friedland N, Liou HL (2003). "Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease". Proc. Natl. Acad. Sci. U.S.A. 100 (5): –. doi:10.1073/pnas.0437840100. PMC 151372. PMID 12591954.
  2. Kristensen O, Kastrup JS, Skov LK, Gajhede M, Larsen JN, Johannessen BR, Bolwig C, Spangfort M, Lund K (2005). "Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity". FEBS Lett. 579 (5): 1208–12. doi:10.1016/j.febslet.2004.11.115. PMID 15710415.

This article incorporates text from the public domain Pfam and InterPro IPR003172

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