MOB1A

MOB kinase activator 1A
PDB rendering based on 1pi1.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1PI1​, 4J1V​, 4JIZ​
Identifiers
Symbols	MOB1A ; C2orf6; MATS1; MOB1; MOBK1B; MOBKL1B; Mob4B
External IDs	OMIM: 609281 MGI: 2442631 HomoloGene: 10076 GeneCards: MOB1A Gene
Gene ontology Molecular function • protein binding • metal ion binding Cellular component • cytosol • extracellular exosome Biological process • hippo signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55233	232157
Ensembl	ENSG00000114978	ENSMUSG00000043131
UniProt	Q9H8S9	Q921Y0
RefSeq (mRNA)	NM_018221	NM_145571
RefSeq (protein)	NP_060691	NP_663546
Location (UCSC)	Chr 2: 74.15 – 74.18 Mb	Chr 6: 83.33 – 83.34 Mb
PubMed search

MOB kinase activator 1A is an enzyme that in humans is encoded by the MOB1A gene.^[1][2]

References

1. Moreno CS, Lane WS, Pallas DC (Jun 2001). "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes". The Journal of Biological Chemistry 276 (26): 24253–60. doi:10.1074/jbc.M102398200. PMC 3503316. PMID 11319234.
2. "Entrez Gene: MOB kinase activator 1A".

Further reading

• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Stavridi ES, Harris KG, Huyen Y, Bothos J, Verwoerd PM, Stayrook SE, Pavletich NP, Jeffrey PD, Luca FC (Sep 2003). "Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways". Structure 11 (9): 1163–70. doi:10.1016/S0969-2126(03)00182-5. PMID 12962634.
• Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (Aug 2004). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". The Journal of Biological Chemistry 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
• Lai ZC, Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, Ho LL, Li Y (Mar 2005). "Control of cell proliferation and apoptosis by mob as tumor suppressor, mats". Cell 120 (5): 675–85. doi:10.1016/j.cell.2004.12.036. PMID 15766530.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Kosaka Y, Mimori K, Tanaka F, Inoue H, Watanabe M, Mori M (Aug 2007). "Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer". International Journal of Oncology 31 (2): 333–8. doi:10.3892/ijo.31.2.333. PMID 17611689.