MORC3

MORC family CW-type zinc finger 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4QQ4​
Identifiers
Symbols	MORC3 ; NXP2; ZCW5; ZCWCC3
External IDs	OMIM: 610078 MGI: 2136841 HomoloGene: 32257 GeneCards: MORC3 Gene
Gene ontology Molecular function • zinc ion binding Cellular component • nucleoplasm • PML body • intermediate filament cytoskeleton Biological process • protein phosphorylation • cell aging • post-embryonic development • peptidyl-serine phosphorylation • negative regulation of fibroblast proliferation • protein stabilization • maintenance of protein location in nucleus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23515	338467
Ensembl	ENSG00000159256	ENSMUSG00000039456
UniProt	Q14149	Q6A0C2
RefSeq (mRNA)	NM_015358	NM_001045529
RefSeq (protein)	NP_056173	NP_001038994
Location (UCSC)	Chr 21: 36.32 – 36.39 Mb	Chr 16: 93.83 – 93.88 Mb
PubMed search

MORC family CW-type zinc finger protein 3 is a protein that in humans is encoded by the MORC3 gene.^[1][2]

This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled-coil domain.^[2]

References

1. Perry J, Zhao Y (Nov 2003). "The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants". Trends Biochem Sci 28 (11): 576–80. doi:10.1016/j.tibs.2003.09.007. PMID 14607086.
2. "Entrez Gene: MORC3 MORC family CW-type zinc finger 3".

Further reading

• Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
• Kimura Y, Sakai F, Nakano O, et al. (2002). "The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains.". J. Biol. Chem. 277 (23): 20611–7. doi:10.1074/jbc.M201440200. PMID 11927593.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rosendorff A, Sakakibara S, Lu S, et al. (2006). "NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5308–13. doi:10.1073/pnas.0601066103. PMC 1459351. PMID 16567619.
• Takahashi K, Yoshida N, Murakami N, et al. (2007). "Dynamic regulation of p53 subnuclear localization and senescence by MORC3.". Mol. Biol. Cell 18 (5): 1701–9. doi:10.1091/mbc.E06-08-0747. PMC 1855011. PMID 17332504.