MPHOSPH1

Kinesin family member 20B
Identifiers
Symbols	KIF20B ; CT90; KRMP1; MPHOSPH1; MPP-1; MPP1
External IDs	OMIM: 605498 MGI: 2444576 HomoloGene: 9418 GeneCards: KIF20B Gene
Gene ontology Molecular function • protein binding • ATP binding • microtubule binding • ATP-dependent microtubule motor activity, plus-end-directed • ATPase activity • protein homodimerization activity • WW domain binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • centrosome • microtubule • midbody • perinuclear region of cytoplasm • spindle midzone • contractile ring • mitotic spindle pole • mitotic spindle midzone Biological process • neural tube closure • microtubule-based movement • cell cycle arrest • mitotic nuclear division • regulation of mitotic nuclear division • metabolic process • positive regulation of cell proliferation • positive regulation of cytokinesis • protein localization to microtubule • neuron projection morphogenesis • cell division • positive regulation of intracellular protein transport • positive regulation of mitotic cytokinetic process • regulation of establishment of cell polarity • positive regulation of neuron migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9585	240641
Ensembl	ENSG00000138182	ENSMUSG00000024795
UniProt	Q96Q89	Q80WE4
RefSeq (mRNA)	NM_001284259	NM_183046
RefSeq (protein)	NP_001271188	NP_898867
Location (UCSC)	Chr 10: 89.7 – 89.77 Mb	Chr 19: 34.92 – 34.98 Mb
PubMed search

Kinesin-like protein KIF20B is a protein that in humans is encoded by the KIF20B gene.^[1][2][3][4]

Interactions

MPHOSPH1 has been shown to interact with PIN1.^[3]

References

1. Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
2. Westendorf JM, Rao PN, Gerace L (Feb 1994). "Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope". Proc Natl Acad Sci U S A 91 (2): 714–8. doi:10.1073/pnas.91.2.714. PMC 43019. PMID 8290587.
3. Kamimoto T, Zama T, Aoki R, Muro Y, Hagiwara M (Oct 2001). "Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1". J Biol Chem 276 (40): 37520–8. doi:10.1074/jbc.M106207200. PMID 11470801.
4. "Entrez Gene: MPHOSPH1 M-phase phosphoprotein 1".

Further reading

• Fritzler MJ, Kerfoot SM, Feasby TE, et al. (2000). "Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1)". J. Investig. Med. 48 (1): 28–39. PMID 10695267.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Abaza A, Soleilhac JM, Westendorf J, et al. (2003). "M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis". J. Biol. Chem. 278 (30): 27844–52. doi:10.1074/jbc.M304522200. PMC 2652640. PMID 12740395.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.