MPP6

Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
Identifiers
Symbols	MPP6 ; PALS2; VAM-1; VAM1; p55T
External IDs	OMIM: 606959 MGI: 1927340 HomoloGene: 22976 GeneCards: MPP6 Gene
Gene ontology Molecular function • protein binding Cellular component • plasma membrane • membrane • extracellular exosome Biological process • protein complex assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51678	56524
Ensembl	ENSG00000105926	ENSMUSG00000038388
UniProt	Q9NZW5	Q9JLB0
RefSeq (mRNA)	NM_001303037	NM_001164733
RefSeq (protein)	NP_001289966	NP_001158205
Location (UCSC)	Chr 7: 24.57 – 24.69 Mb	Chr 6: 50.11 – 50.2 Mb
PubMed search

MAGUK p55 subfamily member 6 is a protein that in humans is encoded by the MPP6 gene.^[1][2][3]

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001).[supplied by OMIM]^[3]

References

1. Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (May 2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J Biol Chem 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959.
2. Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (Apr 2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim Biophys Acta 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
3. "Entrez Gene: MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)".

Further reading

• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Leonoudakis D, Conti LR, Anderson S, et al. (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.