MPST

Mercaptopyruvate sulfurtransferase
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3OLH​, 4JGT​
Identifiers
Symbols	MPST ; MST; TST2; TUM1
External IDs	OMIM: 602496 MGI: 2179733 HomoloGene: 31942 GeneCards: MPST Gene
EC number	2.8.1.2
Gene ontology Molecular function • thiosulfate sulfurtransferase activity • 3-mercaptopyruvate sulfurtransferase activity • identical protein binding Cellular component • mitochondrial inner membrane • cytosol • cell junction • neuron projection • synapse • extracellular exosome Biological process • kidney development • liver development • cyanate catabolic process • response to toxic substance • transsulfuration • spinal cord development • hydrogen sulfide biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4357	246221
Ensembl	ENSG00000128309	ENSMUSG00000071711
UniProt	P25325	D3YYT8
RefSeq (mRNA)	NM_001013436	NM_001162492
RefSeq (protein)	NP_001013454	NP_001155964
Location (UCSC)	Chr 22: 37.02 – 37.03 Mb	Chr 15: 78.41 – 78.41 Mb
PubMed search

3-mercaptopyruvate sulfurtransferase is an enzyme that in humans is encoded by the MPST gene.^[1][2]

This gene encodes a protein which can function as a monomer or as a disulfide-linked homodimer and which catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cyanide degradation and in thiosulfate biosynthesis. The encoded cytoplasmic protein is a member of the rhodanese family but is not rhodanese itself, which is a mitochondrial protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[2]

References

1. Pallini R, Guazzi GC, Cannella C, Cacace MG (Dec 1991). "Cloning and sequence analysis of the human liver rhodanese: comparison with the bovine and chicken enzymes". Biochem Biophys Res Commun 180 (2): 887–93. doi:10.1016/S0006-291X(05)81148-9. PMID 1953758.
2. "Entrez Gene: MPST mercaptopyruvate sulfurtransferase".

Further reading

• Billaut-Laden I, Rat E, Allorge D, et al. (2006). "Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme.". Toxicol. Lett. 165 (2): 101–11. doi:10.1016/j.toxlet.2006.02.002. PMID 16545926.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Aita N, Ishii K, Akamatsu Y, et al. (1997). "Cloning and expression of human liver rhodanese cDNA.". Biochem. Biophys. Res. Commun. 231 (1): 56–60. doi:10.1006/bbrc.1996.6046. PMID 9070219.