MRPL10

Mitochondrial ribosomal protein L10
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3J7Y​, 3J9M​
Identifiers
Symbols	MRPL10 ; L10MT; MRP-L10; MRP-L8; MRPL8; RPML8
External IDs	OMIM: 611825 MGI: 1333801 HomoloGene: 41665 GeneCards: MRPL10 Gene
Gene ontology Molecular function • structural constituent of ribosome • protein binding • poly(A) RNA binding Cellular component • nucleoplasm • mitochondrion • mitochondrial inner membrane • mitochondrial large ribosomal subunit • ribonucleoprotein complex Biological process • translation • organelle organization • mitochondrial translation • ribosome biogenesis • mitochondrial translational initiation • mitochondrial translational elongation • mitochondrial translational termination Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	124995	107732
Ensembl	ENSG00000159111	ENSMUSG00000001445
UniProt	Q7Z7H8	Q3TBW2
RefSeq (mRNA)	NM_145255	NM_026154
RefSeq (protein)	NP_660298	NP_080430
Location (UCSC)	Chr 17: 47.82 – 47.83 Mb	Chr 11: 97.04 – 97.05 Mb
PubMed search

39S ribosomal protein L10, mitochondrial is a protein that in humans is encoded by the MRPL10 gene.^[1][2]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified two transcript variants that encode different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.^[2]

References

1. Koc EC, Burkhart W, Blackburn K, Moyer MB, Schlatzer DM, Moseley A, Spremulli LL (Nov 2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J Biol Chem 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
2. "Entrez Gene: MRPL10 mitochondrial ribosomal protein L10".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang CC, Kadota M, Nishigaki R, et al. (2004). "Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21.". Biochem. Biophys. Res. Commun. 314 (2): 335–50. doi:10.1016/j.bbrc.2003.12.091. PMID 14733910.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1-2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. (1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences.". J. Biol. Chem. 273 (52): 34828–36. doi:10.1074/jbc.273.52.34828. PMID 9857009.
• Piatyszek MA, Denslow ND, O'Brien TW (1988). "RNA binding proteins of the large subunit of bovine mitochondrial ribosomes.". Nucleic Acids Res. 16 (6): 2565–83. doi:10.1093/nar/16.6.2565. PMC 336390. PMID 3129699.