MRPL23

Mitochondrial ribosomal protein L23
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3J7Y​, 3J9M​
Identifiers
Symbols	MRPL23 ; L23MRP; RPL23; RPL23L
External IDs	OMIM: 600789 MGI: 1196612 HomoloGene: 7922 GeneCards: MRPL23 Gene
Gene ontology Molecular function • nucleotide binding • RNA binding • structural constituent of ribosome • protein binding Cellular component • nucleolus • mitochondrion • mitochondrial inner membrane • mitochondrial large ribosomal subunit Biological process • translation • organelle organization • mitochondrial translation • mitochondrial translational initiation • mitochondrial translational elongation • mitochondrial translational termination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6150	19935
Ensembl	ENSG00000214026	ENSMUSG00000037772
UniProt	Q16540	O35972
RefSeq (mRNA)	NM_021134	NM_011288
RefSeq (protein)	NP_066957	NP_035418
Location (UCSC)	Chr 11: 1.95 – 1.98 Mb	Chr 7: 142.53 – 142.54 Mb
PubMed search

39S ribosomal protein L23, mitochondrial is a protein that in humans is encoded by the MRPL23 gene.^[1][2]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11.^[2]

References

1. Tsang P, Gilles F, Yuan L, Kuo YH, Lupu F, Samara G, Moosikasuwan J, Goye A, Zelenetz AD, Selleri L (Feb 1996). "A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues". Hum Mol Genet 4 (9): 1499–507. doi:10.1093/hmg/4.9.1499. PMID 8541832.
2. "Entrez Gene: MRPL23 mitochondrial ribosomal protein L23".

Further reading

• Sun XX, Dai MS, Lu H (2007). "5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction". J. Biol. Chem. 282 (11): 8052–9. doi:10.1074/jbc.M610621200. PMID 17242401.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease". Gene 286 (1): 73–9. doi:10.1016/S0378-1119(01)00808-3. PMID 11943462.
• Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.