MRPL37

Mitochondrial ribosomal protein L37
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3J7Y​, 3J9M​
Identifiers
Symbols	MRPL37 ; L37mt; MRP-L2; MRP-L37; MRPL2; RPML2
External IDs	OMIM: 611843 MGI: 1926268 HomoloGene: 9536 GeneCards: MRPL37 Gene
Gene ontology Molecular function • structural constituent of ribosome • poly(A) RNA binding Cellular component • mitochondrion • mitochondrial inner membrane • mitochondrial ribosome Biological process • translation • organelle organization • mitochondrial translation • mitochondrial translational initiation • mitochondrial translational elongation • mitochondrial translational termination Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51253	56280
Ensembl	ENSG00000116221	ENSMUSG00000028622
UniProt	Q9BZE1	Q921S7
RefSeq (mRNA)	NM_016491	NM_025500
RefSeq (protein)	NP_057575	NP_079776
Location (UCSC)	Chr 1: 54.18 – 54.23 Mb	Chr 4: 107.06 – 107.07 Mb
PubMed search

39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene.^[1][2]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.^[2]

References

1. Graack HR, Bryant ML, O'Brien TW (Jan 2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry 38 (50): 16569–77. doi:10.1021/bi991543s. PMID 10600119.
2. "Entrez Gene: MRPL37 mitochondrial ribosomal protein L37".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Levshenkova EV, Ukraintsev KE, Orlova VV, et al. (2005). "[The structure and specific features of the cDNA expression of the human gene MRPL37]". Bioorg. Khim. 30 (5): 499–506. PMID 15562971.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1-2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.