Mitochondrial ribosomal protein L42

Mitochondrial ribosomal protein L42
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MRPL42 ; HSPC204; L31MT; L42MT; MRP-L31; MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT
External IDs OMIM: 611847 MGI: 1196413 HomoloGene: 12106 GeneCards: MRPL42 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 28977 67270
Ensembl ENSG00000198015 ENSMUSG00000062981
UniProt Q9Y6G3 Q9CPV3
RefSeq (mRNA) NM_014050 NM_026065
RefSeq (protein) NP_054769 NP_080341
Location (UCSC) Chr 12:
93.47 – 93.52 Mb
Chr 10:
95.48 – 95.5 Mb
PubMed search

28S ribosomal protein L42, mitochondrial is a protein that in humans is encoded by the MRPL42 gene.[1][2][3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Further experiments will be needed to identify the specific subunit localization. Sequence analysis identified three transcript variants that encode two different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q.[3]

References

  1. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  2. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  3. 1 2 "Entrez Gene: MRPL42 mitochondrial ribosomal protein L42".

Further reading

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