MRPS18B

Mitochondrial ribosomal protein S18B
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3J9M​
Identifiers
Symbols	MRPS18B ; C6orf14; HSPC183; HumanS18a; MRP-S18-2; MRPS18-2; PTD017; S18amt
External IDs	OMIM: 611982 MGI: 1914223 HomoloGene: 32205 GeneCards: MRPS18B Gene
Gene ontology Molecular function • structural constituent of ribosome Cellular component • nucleoplasm • mitochondrion • mitochondrial inner membrane • mitochondrial small ribosomal subunit • cell junction Biological process • translation • organelle organization • mitochondrial translation • mitochondrial translational initiation • mitochondrial translational elongation • mitochondrial translational termination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	28973	66973
Ensembl	ENSG00000203624	ENSMUSG00000024436
UniProt	Q9Y676	Q99N84
RefSeq (mRNA)	NM_014046	NM_025878
RefSeq (protein)	NP_054765	NP_080154
Location (UCSC)	Chr 6: 30.62 – 30.63 Mb	Chr 17: 35.91 – 35.92 Mb
PubMed search

28S ribosomal protein S18b, mitochondrial is a protein that in humans is encoded by the MRPS18B gene.^[1][2]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q.^[2]

References

1. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
2. "Entrez Gene: MRPS18B mitochondrial ribosomal protein S18B".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.". Genetics 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC 1526686. PMID 16702430.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit.". J. Biol. Chem. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.