MRPS6

Mitochondrial ribosomal protein S6
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3J9M​
Identifiers
Symbols	MRPS6 ; C21orf101; MRP-S6; RPMS6; S6mt
External IDs	OMIM: 611973 MGI: 2153111 HomoloGene: 41871 GeneCards: MRPS6 Gene
Gene ontology Molecular function • structural constituent of ribosome • protein binding • small ribosomal subunit rRNA binding Cellular component • mitochondrial inner membrane • mitochondrial small ribosomal subunit • small ribosomal subunit Biological process • translation • organelle organization • mitochondrial translation • mitochondrial translational initiation • mitochondrial translational elongation • mitochondrial translational termination Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64968	121022
Ensembl	ENSG00000243927	ENSMUSG00000039680
UniProt	P82932	P58064
RefSeq (mRNA)	NM_032476	NM_080456
RefSeq (protein)	NP_115865	NP_536704
Location (UCSC)	Chr 21: 34.07 – 34.14 Mb	Chr 16: 92.06 – 92.11 Mb
PubMed search

28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the MRPS6 gene.^[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q.^[1]

References

1. "Entrez Gene: MRPS6 mitochondrial ribosomal protein S6".

Further reading

• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
• Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present.". J. Biol. Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit.". J. Biol. Chem. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1-2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Reymond A, Camargo AA, Deutsch S, et al. (2002). "Nineteen additional unpredicted transcripts from human chromosome 21.". Genomics 79 (6): 824–32. doi:10.1006/geno.2002.6781. PMID 12036297.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.