MSRB2
| Methionine sulfoxide reductase B2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MSRB2 ; CBS-1; CBS1; CGI-131; MSRB; PILB | ||||||||||||
| External IDs | OMIM: 613782 MGI: 1923717 HomoloGene: 56555 GeneCards: MSRB2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 22921 | 76467 | |||||||||||
| Ensembl | ENSG00000148450 | ENSMUSG00000023094 | |||||||||||
| UniProt | Q9Y3D2 | Q78J03 | |||||||||||
| RefSeq (mRNA) | NM_012228 | NM_029619 | |||||||||||
| RefSeq (protein) | NP_036360 | NP_083895 | |||||||||||
| Location (UCSC) |
Chr 10: 23.1 – 23.12 Mb |
Chr 2: 19.37 – 19.39 Mb | |||||||||||
| PubMed search | |||||||||||||
Methionine-R-sulfoxide reductase B2, mitochondrial is an enzyme that in humans is encoded by the MSRB2 gene.[1][2][3] The MRSB2 enzyme catalyzes the reduction of methionine sulfoxide to methionine.
See also
References
- ↑ Escribano J, Ortego J, Coca-Prados M (Jan 1997). "Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins". J Biochem 118 (5): 921–31. PMID 8749308.
- ↑ Huang W, Escribano J, Sarfarazi M, Coca-Prados M (Aug 1999). "Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases". Gene 233 (1-2): 233–40. doi:10.1016/S0378-1119(99)00131-6. PMID 10375640.
- ↑ "Entrez Gene: MSRB2 methionine sulfoxide reductase B2".
Further reading
- Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
- Jung S, Hansel A, Kasperczyk H, et al. (2002). "Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1". FEBS Lett. 527 (1-3): 91–4. doi:10.1016/S0014-5793(02)03171-X. PMID 12220640.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kim HY, Gladyshev VN (2004). "Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases". Mol. Biol. Cell 15 (3): 1055–64. doi:10.1091/mbc.E03-08-0629. PMC 363075. PMID 14699060.
- Picot CR, Perichon M, Cintrat JC, et al. (2004). "The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts". FEBS Lett. 558 (1-3): 74–8. doi:10.1016/S0014-5793(03)01530-8. PMID 14759519.
- Hansel A, Jung S, Hoshi T, Heinemann SH (2004). "A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1". Redox Rep. 8 (6): 384–8. doi:10.1179/135100003225003429. PMID 14980072.
- Schallreuter KU, Rübsam K, Chavan B, et al. (2006). "Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus". Biochem. Biophys. Res. Commun. 342 (1): 145–52. doi:10.1016/j.bbrc.2006.01.124. PMID 16480945.
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