MTCP1

Mature T-cell proliferation 1
PDB rendering based on 1a1x.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1A1X​, 1QTT​, 1QTU​
Identifiers
Symbols	MTCP1 ; P13MTCP1; p8MTCP1
External IDs	OMIM: 300116 MGI: 102699 HomoloGene: 82921 GeneCards: MTCP1 Gene
Gene ontology Cellular component • mitochondrion Biological process • cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4515	17763
Ensembl	ENSG00000214827	ENSMUSG00000031200
UniProt	P56278	Q60945
RefSeq (mRNA)	NM_001018025	NM_001039373.4
RefSeq (protein)	NP_001018025	NP_001034462.1
Location (UCSC)	Chr X: 155.06 – 155.15 Mb	Chr X: 72.65 – 72.66 Mb
PubMed search

Protein p13 MTCP-1 is a protein that in humans is encoded by the MTCP1 gene.^[1][2][3][4]

Function

This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. The gene has two ORFs that encode two different proteins. The upstream ORF encodes a 13kDa protein that is a member of the TCL1 family; this protein may be involved in leukemogenesis. The downstream ORF encodes an 8kDa protein that localizes to mitochondria. Alternative splicing results in multiple transcript variants.^[4]

Interactions

MTCP1 has been shown to interact with AKT1.^[5][6]

References

1. Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A, Sigaux F, Kirsch IR (September 1993). "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations". Oncogene 8 (9): 2475–83. PMID 8361760.
2. Madani A, Choukroun V, Soulier J, Cacheux V, Claisse JF, Valensi F, Daliphard S, Cazin B, Levy V, Leblond V, Daniel MT, Sigaux F, Stern MH (July 1996). "Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations". Blood 87 (5): 1923–7. PMID 8634440.
3. Yang YS, Guignard L, Padilla A, Hoh F, Strub MP, Stern MH, Lhoste JM, Roumestand C (September 1998). "Solution structure of the recombinant human oncoprotein p13MTCP1". J Biomol NMR 11 (3): 337–54. doi:10.1023/A:1008279616063. PMID 9691281.
4. "Entrez Gene: MTCP1 mature T-cell proliferation 1".
5. Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
6. Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.

Further reading

• Kenwrick S, Levinson B, Taylor S, Shapiro A, Gitschier J (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175.
• Madani A, Soulier J, Schmid M, Plichtova R, Lermé F, Gateau-Roesch O, Garnier JP, Pla M, Sigaux F, Stern MH (1995). "The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein". Oncogene 10 (11): 2259–62. PMID 7784073.
• Soulier J, Madani A, Cacheux V, Rosenzwajg M, Sigaux F, Stern MH (1994). "The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation". Oncogene 9 (12): 3565–70. PMID 7970717.
• Thick J, Mak YF, Metcalfe J, Beatty D, Taylor AM (1994). "A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia". Leukemia 8 (4): 564–73. PMID 8152252.
• Fisch P, Forster A, Sherrington PD, Dyer MJ, Rabbitts TH (1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another". Oncogene 8 (12): 3271–6. PMID 8247530.
• Gritti C, Choukroun V, Soulier J, Madani A, Dastot H, Leblond V, Radford-Weiss I, Valensi F, Varet B, Sigaux F, Stern MH (1997). "Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations". Oncogene 15 (11): 1329–35. doi:10.1038/sj.onc.1201303. PMID 9315101.
• Barthe P, Yang YS, Chiche L, Hoh F, Strub MP, Guignard L, Soulier J, Stern MH, van Tilbeurgh H, Lhoste JM, Roumestand C (1998). "Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif". J. Mol. Biol. 274 (5): 801–15. doi:10.1006/jmbi.1997.1438. PMID 9405159.
• Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Varnum J, Germann MW, Croce CM (1998). "Purification and characterization of recombinant forms of TCL-1 and MTCP-1 proteins". Protein Expr. Purif. 12 (2): 215–25. doi:10.1006/prep.1997.0822. PMID 9518463.
• Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW (1998). "Crystal structure of MTCP-1: Implications for role of TCL-1 and MTCP-1 in T cell malignancies". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3413–8. doi:10.1073/pnas.95.7.3413. PMC 19850. PMID 9520380.
• Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C (2000). "Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data". J. Biomol. NMR 17 (3): 215–30. doi:10.1023/A:1008386110930. PMID 10959629.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.