MTSS1

Metastasis suppressor 1
PDB rendering based on 2d1k.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2D1K​
Identifiers
Symbols	MTSS1 ; MIM; MIMA; MIMB
External IDs	OMIM: 608486 MGI: 2384818 HomoloGene: 8841 GeneCards: MTSS1 Gene
Gene ontology Molecular function • actin monomer binding • receptor binding • protein binding • identical protein binding • actin filament binding Cellular component • ruffle • cytoplasm • adherens junction • actin cytoskeleton • endocytic vesicle Biological process • in utero embryonic development • positive regulation of defense response to virus by host • movement of cell or subcellular component • plasma membrane organization • cell adhesion • transmembrane receptor protein tyrosine kinase signaling pathway • magnesium ion homeostasis • microspike assembly • actin cytoskeleton organization • actin filament polymerization • bone mineralization • positive regulation of actin filament bundle assembly • adherens junction maintenance • negative regulation of epithelial cell proliferation • renal tubule morphogenesis • cellular response to fluid shear stress • glomerulus morphogenesis • nephron tubule epithelial cell differentiation • epithelial cell proliferation involved in renal tubule morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9788	211401
Ensembl	ENSG00000170873	ENSMUSG00000022353
UniProt	O43312	Q8R1S4
RefSeq (mRNA)	NM_001282971	NM_001146180
RefSeq (protein)	NP_001269900	NP_001139652
Location (UCSC)	Chr 8: 124.55 – 124.73 Mb	Chr 15: 58.94 – 59.08 Mb
PubMed search

Metastasis suppressor protein 1 is a protein that in humans is encoded by the MTSS1 gene.^[1][2][3] True to its name, it codes for a metastasis suppressor.

References

1. Mattila PK, Salminen M, Yamashiro T, Lappalainen P (Mar 2003). "Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain". J Biol Chem 278 (10): 8452–9. doi:10.1074/jbc.M212113200. PMID 12482861.
2. Lee YG, Macoska JA, Korenchuk S, Pienta KJ (Jun 2002). "MIM, a Potential Metastasis Suppressor Gene in Bladder Cancer". Neoplasia 4 (4): 291–4. doi:10.1038/sj.neo.7900231. PMC 1531703. PMID 12082544.
3. "Entrez Gene: MTSS1 metastasis suppressor 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Woodings JA, Sharp SJ, Machesky LM (2003). "MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta". Biochem. J. 371 (Pt 2): 463–71. doi:10.1042/BJ20021962. PMC 1223315. PMID 12570871.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yamagishi A, Masuda M, Ohki T, et al. (2004). "A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein". J. Biol. Chem. 279 (15): 14929–36. doi:10.1074/jbc.M309408200. PMID 14752106.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
• Nixdorf S, Grimm MO, Loberg R, et al. (2004). "Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines". Cancer Lett. 215 (2): 209–20. doi:10.1016/j.canlet.2004.05.002. PMID 15488640.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Callahan CA, Ofstad T, Horng L, et al. (2004). "MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription". Genes Dev. 18 (22): 2724–9. doi:10.1101/gad.1221804. PMC 528890. PMID 15545630.
• Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE (2005). "Receptor tyrosine phosphatase–dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4". J. Cell Biol. 168 (3): 453–63. doi:10.1083/jcb.200409078. PMC 2171717. PMID 15684034.
• Bompard G, Sharp SJ, Freiss G, Machesky LM (2006). "Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B". J. Cell. Sci. 118 (Pt 22): 5393–403. doi:10.1242/jcs.02640. PMID 16280553.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Utikal J, Gratchev A, Muller-Molinet I, et al. (2006). "The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation". Int. J. Cancer 119 (10): 2287–93. doi:10.1002/ijc.22106. PMID 16921485.
• Ma S, Guan XY, Lee TK, Chan KW (2007). "Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma". Hum. Pathol. 38 (8): 1201–6. doi:10.1016/j.humpath.2007.01.004. PMID 17442377.