MTUS1

Microtubule associated tumor suppressor 1
Identifiers
Symbols	MTUS1 ; ATBP; ATIP; ICIS; MP44; MTSG1
External IDs	OMIM: 609589 MGI: 2142572 HomoloGene: 100292 GeneCards: MTUS1 Gene
Gene ontology Molecular function • receptor activity • oxidoreductase activity • transition metal ion binding Cellular component • extracellular space • nucleus • mitochondrion • Golgi apparatus • microtubule organizing center • spindle • microtubule • plasma membrane Biological process • cellular response to peptide hormone stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57509	102103
Ensembl	ENSG00000129422	ENSMUSG00000045636
UniProt	Q9ULD2	Q5HZI1
RefSeq (mRNA)	NM_001001924	NM_001005863
RefSeq (protein)	NP_001001924	NP_001005863
Location (UCSC)	Chr 8: 17.64 – 17.8 Mb	Chr 8: 40.99 – 41.13 Mb
PubMed search

Mitochondrial tumor suppressor 1 is a protein that in humans is encoded by the MTUS1 gene.^[1][2][3]

Function

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and participates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.^[3]

Interactions

MTUS1 has been shown to interact with Angiotensin II receptor type 2.^[4]

References

1. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
2. Seibold S, Rudroff C, Weber M, Galle J, Wanner C, Marx M (Jun 2003). "Identification of a new tumor suppressor gene located at chromosome 8p21.3-22". FASEB Journal 17 (9): 1180–2. doi:10.1096/fj.02-0934fje. PMID 12692079.
3. "Entrez Gene: MTUS1 mitochondrial tumor suppressor 1".
4. Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (Jul 2004). "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP". The Journal of Biological Chemistry 279 (28): 28989–97. doi:10.1074/jbc.M403880200. PMID 15123706.

Further reading

• Di Benedetto M, Pineau P, Nouet S, Berhouet S, Seitz I, Louis S, Dejean A, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Nahmias C (Jun 2006). "Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma". Molecular and Cellular Endocrinology 252 (1-2): 207–15. doi:10.1016/j.mce.2006.03.014. PMID 16650523.
• Frank B, Bermejo JL, Hemminki K, Sutter C, Wappenschmidt B, Meindl A, Kiechle-Bahat M, Bugert P, Schmutzler RK, Bartram CR, Burwinkel B (Jul 2007). "Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk". Carcinogenesis 28 (7): 1442–5. doi:10.1093/carcin/bgm033. PMID 17301065.
• Di Benedetto M, Bièche I, Deshayes F, Vacher S, Nouet S, Collura V, Seitz I, Louis S, Pineau P, Amsellem-Ouazana D, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Lidereau R, Nahmias C (Oct 2006). "Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP". Gene 380 (2): 127–36. doi:10.1016/j.gene.2006.05.021. PMID 16887298.
• Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (Jul 2004). "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP". The Journal of Biological Chemistry 279 (28): 28989–97. doi:10.1074/jbc.M403880200. PMID 15123706.