MYO18A

Myosin XVIIIA
Identifiers
Symbols	MYO18A ; MYSPDZ; SPR210
External IDs	OMIM: 610067 MGI: 2667185 HomoloGene: 7977 GeneCards: MYO18A Gene
Gene ontology Molecular function • DNA binding • protein binding • ATP binding • ATPase activity • ADP binding • poly(A) RNA binding • actin filament binding Cellular component • Golgi membrane • endoplasmic reticulum-Golgi intermediate compartment • trans-Golgi network • membrane • myosin complex • actomyosin Biological process • DNA metabolic process • Golgi organization • cell migration • actomyosin structure organization • negative regulation of apoptotic process • Golgi vesicle budding • positive regulation of protein secretion • Golgi ribbon formation • asymmetric Golgi ribbon formation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	399687	360013
Ensembl	ENSG00000196535	ENSMUSG00000000631
UniProt	Q92614	Q9JMH9
RefSeq (mRNA)	NM_078471	NM_001291212
RefSeq (protein)	NP_510880	NP_001278141
Location (UCSC)	Chr 17: 29.07 – 29.18 Mb	Chr 11: 77.76 – 77.87 Mb
PubMed search

Myosin-XVIIIa is a protein that in humans is encoded by the MYO18A gene.^[1][2]

References

1. Mori K, Furusawa T, Okubo T, Inoue T, Ikawa S, Yanai N, Mori KJ, Obinata M (May 2003). "Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)". J Biochem 133 (4): 405–13. doi:10.1093/jb/mvg053. PMID 12761286.
2. "Entrez Gene: MYO18A myosin XVIIIA".

Further reading

• Chroneos ZC, Abdolrasulnia R, Whitsett JA, et al. (1996). "Purification of a cell-surface receptor for surfactant protein A.". J. Biol. Chem. 271 (27): 16375–83. doi:10.1074/jbc.271.27.16375. PMID 8663107.
• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Chang NS, Mattison J, Cao H, et al. (1999). "Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity.". Biochem. Biophys. Res. Commun. 253 (3): 743–9. doi:10.1006/bbrc.1998.9846. PMID 9918798.
• Ji H, Zhai Q, Zhu J, et al. (2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival.". Biochem. Biophys. Res. Commun. 270 (1): 267–71. doi:10.1006/bbrc.2000.2413. PMID 10733938.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Homma K, Kikuno RF, Nagase T, et al. (2004). "Alternative splice variants encoding unstable protein domains exist in the human brain.". J. Mol. Biol. 343 (5): 1207–20. doi:10.1016/j.jmb.2004.09.028. PMID 15491607.
• Isogawa Y, Kon T, Inoue T, et al. (2005). "The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site.". Biochemistry 44 (16): 6190–6. doi:10.1021/bi0475931. PMID 15835906.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Yang CH, Szeliga J, Jordan J, et al. (2005). "Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A.". J. Biol. Chem. 280 (41): 34447–57. doi:10.1074/jbc.M505229200. PMC 1762002. PMID 16087679.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.