MYO1F

Myosin IF
Identifiers
Symbol	MYO1F
External IDs	OMIM: 601480 MGI: 107711 HomoloGene: 56276 GeneCards: MYO1F Gene
Gene ontology Molecular function • motor activity • actin binding • calmodulin binding • ATP binding Cellular component • unconventional myosin complex • cortical actin cytoskeleton • filamentous actin Biological process • negative regulation of cell adhesion • biological_process • metabolic process • positive regulation of cell migration • regulation of actin cytoskeleton organization • neutrophil degranulation • regulation of innate immune response • defense response to Gram-positive bacterium Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4542	17916
Ensembl	ENSG00000142347	ENSMUSG00000024300
UniProt	O00160	n/a
RefSeq (mRNA)	NM_012335	NM_053214
RefSeq (protein)	NP_036467	NP_444444
Location (UCSC)	Chr 19: 8.52 – 8.58 Mb	Chr 17: 33.56 – 33.61 Mb
PubMed search

Myosin-If is a protein that in humans is encoded by the MYO1F gene.^[1][2][3]

It is expressed mainly in the immune system and might be involved in cell adhesion and motility.^[4] It is a candidate gene for (among other things) nonsyndromic deafness.^[5]

References

1. Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics 40 (2): 332–41. doi:10.1006/geno.1996.4526. PMID 9119401.
2. Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Feb 1997). "Mapping of unconventional myosins in mouse and human". Genomics 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.
3. "Entrez Gene: MYO1F myosin IF".
4. Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA (October 2006). "Modulation of cell adhesion and motility in the immune system by Myo1f". Science 314 (5796): 136–9. doi:10.1126/science.1131920. PMID 17023661.
5. Chen AH, Stephan DA, Hasson T, Fukushima K, Nelissen CM, Chen AF, Jun AI, Ramesh A, Van Camp G, Smith RJ (August 2001). "MYO1F as a candidate gene for nonsyndromic deafness, DFNB15". Arch. Otolaryngol. Head Neck Surg. 127 (8): 921–5. doi:10.1001/archotol.127.8.921. PMID 11493199.

Further reading

• Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
• Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol. Cell 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.