MYO3A

Myosin IIIA
Identifiers
Symbols	MYO3A ; DFNB30
External IDs	OMIM: 606808 MGI: 2183924 HomoloGene: 49486 IUPHAR: 2112 ChEMBL: 5546 GeneCards: MYO3A Gene
EC number	2.7.11.1
Gene ontology Molecular function • microfilament motor activity • protein kinase activity • protein serine/threonine kinase activity • calmodulin binding • ATP binding • actin-dependent ATPase activity • ADP binding • actin filament binding • plus-end directed microfilament motor activity Cellular component • photoreceptor inner segment • cytoplasm • myosin complex • filopodium • filamentous actin • stereocilium bundle tip • filopodium tip Biological process • visual perception • sensory perception of sound • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • protein autophosphorylation • inner ear development • response to stimulus • positive regulation of filopodium assembly Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53904	667663
Ensembl	ENSG00000095777	ENSMUSG00000025716
UniProt	Q8NEV4	A2ASW0
RefSeq (mRNA)	NM_017433	NM_148413
RefSeq (protein)	NP_059129	NP_680779
Location (UCSC)	Chr 10: 25.93 – 26.21 Mb	Chr 2: 22.23 – 22.62 Mb
PubMed search

Myosin IIIA is a protein that in humans is encoded by the MYO3A gene.^[1][2]

The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.^[2]

References

1. Dose AC, Burnside B (Sep 2000). "Cloning and chromosomal localization of a human class III myosin". Genomics 67 (3): 333–42. doi:10.1006/geno.2000.6256. PMID 10936054.
2. "Entrez Gene: MYO3A myosin IIIA".

Further reading

• Walsh T, Walsh V, Vreugde S, et al. (2002). "From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30.". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7518–23. doi:10.1073/pnas.102091699. PMC 124268. PMID 12032315.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Komaba S, Inoue A, Maruta S, et al. (2003). "Determination of human myosin III as a motor protein having a protein kinase activity.". J. Biol. Chem. 278 (24): 21352–60. doi:10.1074/jbc.M300757200. PMID 12672820.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Kambara T, Komaba S, Ikebe M (2007). "Human myosin III is a motor having an extremely high affinity for actin.". J. Biol. Chem. 281 (49): 37291–301. doi:10.1074/jbc.M603823200. PMID 17012748.
• Schneider ME, Dosé AC, Salles FT, et al. (2006). "A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression.". J. Neurosci. 26 (40): 10243–52. doi:10.1523/JNEUROSCI.2812-06.2006. PMID 17021180.
• Dosé AC, Ananthanarayanan S, Moore JE, et al. (2007). "Kinetic mechanism of human myosin IIIA.". J. Biol. Chem. 282 (1): 216–31. doi:10.1074/jbc.M605964200. PMID 17074769.