MYO6

Myosin VI
PDB rendering based on 2bkh.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2bkh​, 2bki​
Identifiers
Symbols	MYO6 ; DFNA22; DFNB37
External IDs	OMIM: 600970 MGI: 104785 HomoloGene: 56417 GeneCards: MYO6 Gene
Gene ontology Molecular function • motor activity • actin binding • protein binding • calmodulin binding • ATP binding • ADP binding • actin filament binding • minus-end directed microfilament motor activity Cellular component • ruffle • nucleus • nucleoplasm • cytoplasm • lysosomal membrane • Golgi apparatus • cytosol • plasma membrane • microvillus • coated pit • cell cortex • membrane • cytoplasmic membrane-bounded vesicle • unconventional myosin complex • DNA-directed RNA polymerase II, holoenzyme • endocytic vesicle • axon • clathrin-coated vesicle membrane • filamentous actin • nuclear membrane • ruffle membrane • neuronal cell body • apical part of cell • clathrin-coated endocytic vesicle • perinuclear region of cytoplasm • extracellular exosome Biological process • protein targeting • intracellular protein transport • endocytosis • synaptic transmission • synapse assembly • sensory perception of sound • locomotory behavior • metabolic process • glutamate secretion • dendrite development • actin filament-based movement • DNA damage response, signal transduction by p53 class mediator • inner ear morphogenesis • auditory receptor cell differentiation • response to drug • positive regulation of transcription from RNA polymerase II promoter • regulation of synaptic plasticity • regulation of secretion • membrane organization • cellular response to electrical stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4646	17920
Ensembl	ENSG00000196586	ENSMUSG00000033577
UniProt	Q9UM54	E9PVU0
RefSeq (mRNA)	NM_001300899	NM_001039546
RefSeq (protein)	NP_001287828	NP_001034635
Location (UCSC)	Chr 6: 75.75 – 75.92 Mb	Chr 9: 80.17 – 80.31 Mb
PubMed search

Myosin VI, also known as MYO6, is a protein. It has been found in humans, mice, fruit flies (Drosophila melanogaster), and nematodes (Caenorhabditis elegans).

Function

Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins.[supplied by OMIM]^[1]

Interactions

MYO6 has been shown to interact with GIPC1^[2][3] and DAB2.^[4][5]

References

1. "Entrez Gene: MYO6 myosin VI".
2. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
3. Aschenbrenner L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Molecular Biology of the Cell 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860.
4. Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127.
5. Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.

Further reading

• Buss F, Luzio JP, Kendrick-Jones J (Nov 2001). "Myosin VI, a new force in clathrin mediated endocytosis". FEBS Letters 508 (3): 295–9. doi:10.1016/S0014-5793(01)03065-4. PMID 11728438.
• Hasson T (Sep 2003). "Myosin VI: two distinct roles in endocytosis". Journal of Cell Science 116 (Pt 17): 3453–61. doi:10.1242/jcs.00669. PMID 12893809.
• Avraham KB, Hasson T, Steel KP, Kingsley DM, Russell LB, Mooseker MS, Copeland NG, Jenkins NA (Dec 1995). "The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells". Nature Genetics 11 (4): 369–75. doi:10.1038/ng1295-369. PMID 7493015.
• Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (Jul 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America 91 (14): 6549–53. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
• Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Avraham KB, Hasson T, Sobe T, Balsara B, Testa JR, Skvorak AB, Morton CC, Copeland NG, Jenkins NA (Aug 1997). "Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice". Human Molecular Genetics 6 (8): 1225–31. doi:10.1093/hmg/6.8.1225. PMID 9259267.
• Buss F, Kendrick-Jones J, Lionne C, Knight AE, Côté GP, Paul Luzio J (Dec 1998). "The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation". The Journal of Cell Biology 143 (6): 1535–45. doi:10.1083/jcb.143.6.1535. PMC 2132970. PMID 9852149.
• Wells AL, Lin AW, Chen LQ, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA, Sweeney HL (Sep 1999). "Myosin VI is an actin-based motor that moves backwards". Nature 401 (6752): 505–8. doi:10.1038/46835. PMID 10519557.
• Buss F, Arden SD, Lindsay M, Luzio JP, Kendrick-Jones J (Jul 2001). "Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis". The EMBO Journal 20 (14): 3676–84. doi:10.1093/emboj/20.14.3676. PMC 125554. PMID 11447109.
• Melchionda S, Ahituv N, Bisceglia L, Sobe T, Glaser F, Rabionet R, Arbones ML, Notarangelo A, Di Iorio E, Carella M, Zelante L, Estivill X, Avraham KB, Gasparini P (Sep 2001). "MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss". American Journal of Human Genetics 69 (3): 635–40. doi:10.1086/323156. PMC 1235492. PMID 11468689.
• Yoshimura M, Homma K, Saito J, Inoue A, Ikebe R, Ikebe M (Oct 2001). "Dual regulation of mammalian myosin VI motor function". The Journal of Biological Chemistry 276 (43): 39600–7. doi:10.1074/jbc.M105080200. PMID 11517222.
• Rock RS, Rice SE, Wells AL, Purcell TJ, Spudich JA, Sweeney HL (Nov 2001). "Myosin VI is a processive motor with a large step size". Proceedings of the National Academy of Sciences of the United States of America 98 (24): 13655–9. doi:10.1073/pnas.191512398. PMC 61096. PMID 11707568.
• Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.
• Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127.
• Wu H, Nash JE, Zamorano P, Garner CC (Aug 2002). "Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking". The Journal of Biological Chemistry 277 (34): 30928–34. doi:10.1074/jbc.M203735200. PMID 12050163.
• Ahmed ZM, Morell RJ, Riazuddin S, Gropman A, Shaukat S, Ahmad MM, Mohiddin SA, Fananapazir L, Caruso RC, Husnain T, Khan SN, Riazuddin S, Griffith AJ, Friedman TB, Wilcox ER (May 2003). "Mutations of MYO6 are associated with recessive deafness, DFNB37". American Journal of Human Genetics 72 (5): 1315–22. doi:10.1086/375122. PMC 1180285. PMID 12687499.
• Aschenbrenner L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Molecular Biology of the Cell 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860.