MYO9B

Myosin IXB
Identifiers
Symbols	MYO9B ; CELIAC4; MYR5
External IDs	OMIM: 602129 MGI: 106624 HomoloGene: 3058 GeneCards: MYO9B Gene
Gene ontology Molecular function • microfilament motor activity • actin binding • GTPase activator activity • protein binding • calmodulin binding • ATP binding • ATPase activity • protein homodimerization activity • ADP binding • metal ion binding Cellular component • ruffle • cytoplasm • cytosol • cell cortex • actin cytoskeleton • membrane • myosin complex • lamellipodium • filamentous actin • filopodium tip • perinuclear region of cytoplasm Biological process • monocyte chemotaxis • small GTPase mediated signal transduction • Rho protein signal transduction • metabolic process • establishment of cell polarity • actin filament-based movement • ARF protein signal transduction • positive regulation of GTPase activity • macrophage chemotaxis • regulation of small GTPase mediated signal transduction • lamellipodium morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4650	17925
Ensembl	ENSG00000099331	ENSMUSG00000004677
UniProt	Q13459	Q9QY06
RefSeq (mRNA)	NM_001130065	NM_001142322
RefSeq (protein)	NP_001123537	NP_001135794
Location (UCSC)	Chr 19: 17.08 – 17.21 Mb	Chr 8: 71.27 – 71.36 Mb
PubMed search

Myosin-IXb is a protein that in humans is encoded by the MYO9B gene.^[1][2]

References

1. Bahler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS (Sep 1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics 43 (1): 107–9. doi:10.1006/geno.1997.4776. PMID 9226381.
2. "Entrez Gene: MYO9B myosin IXB".

Further reading

• Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
• Wirth JA, Jensen KA, Post PL, et al. (1997). "Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail.". J. Cell. Sci. 109 (3): 653–61. PMID 8907710.
• Post PL, Bokoch GM, Mooseker MS (1998). "Human myosin-IXb is a mechanochemically active motor and a GAP for rho.". J. Cell. Sci. 111 (7): 941–50. PMID 9490638.
• Grewal PK, Jones AM, Maconochie M, et al. (2000). "Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing.". Gene 240 (2): 389–98. doi:10.1016/S0378-1119(99)00459-X. PMID 10580159.
• Post PL, Tyska MJ, O'Connell CB, et al. (2002). "Myosin-IXb is a single-headed and processive motor.". J. Biol. Chem. 277 (14): 11679–83. doi:10.1074/jbc.M111173200. PMID 11801597.
• Inoue A, Saito J, Ikebe R, Ikebe M (2002). "Myosin IXb is a single-headed minus-end-directed processive motor.". Nat. Cell Biol. 4 (4): 302–6. doi:10.1038/ncb774. PMID 11901422.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Van Belzen MJ, Meijer JW, Sandkuijl LA, et al. (2003). "A major non-HLA locus in celiac disease maps to chromosome 19.". Gastroenterology 125 (4): 1032–41. doi:10.1016/S0016-5085(03)01205-8. PMID 14517787.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity.". J. Biol. Chem. 280 (11): 10128–34. doi:10.1074/jbc.M413415200. PMID 15644318.
• Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
• Monsuur AJ, de Bakker PI, Alizadeh BZ, et al. (2006). "Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect.". Nat. Genet. 37 (12): 1341–4. doi:10.1038/ng1680. PMID 16282976.
• Kambara T, Ikebe M (2006). "A unique ATP hydrolysis mechanism of single-headed processive myosin, myosin IX.". J. Biol. Chem. 281 (8): 4949–57. doi:10.1074/jbc.M509141200. PMID 16338935.
• Nishikawa M, Nishikawa S, Inoue A, et al. (2006). "A unique mechanism for the processive movement of single-headed myosin-IX.". Biochem. Biophys. Res. Commun. 343 (4): 1159–64. doi:10.1016/j.bbrc.2006.03.057. PMID 16616011.
• Amundsen SS, Monsuur AJ, Wapenaar MC, et al. (2006). "Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort.". Hum. Immunol. 67 (4-5): 341–5. doi:10.1016/j.humimm.2006.03.020. PMID 16720215.
• Giordano M, Marano C, Mellai M, et al. (2007). "A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population.". Genes Immun. 7 (7): 606–8. doi:10.1038/sj.gene.6364331. PMID 16943798.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• van Bodegraven AA, Curley CR, Hunt KA, et al. (2007). "Genetic variation in myosin IXB is associated with ulcerative colitis.". Gastroenterology 131 (6): 1768–74. doi:10.1053/j.gastro.2006.09.011. PMID 17087940.
• Núñez C, Márquez A, Varadé J, et al. (2007). "No evidence of association of the MYO9B polymorphisms with celiac disease in the Spanish population.". Tissue Antigens 68 (6): 489–92. doi:10.1111/j.1399-0039.2006.00699.x. PMID 17176439.