Magnetic resonance microscopy

Magnetic resonance microscopy (MRM, µMRI) is magnetic resonance imaging (MRI) at a microscopic level down to the scale of 5-10 µm³.[1] The first definition of MRM was MRI having voxel resolutions of better than 100 µm³.[2]

Nomenclature

Magnetic resonance microscopy refers to very high resolution MRI imaging (down to nanometer scale, in some cases comparable with histopathology). The term MR microscopy is most widely used by the High Resolution Magnetic Resonance Imaging department at Duke University, headed by Dr. G. Allan Johnson, and the National High Magnetic Field Lab group at AMRIS, University of Florida/Florida State University.[3]

Differences between MRI and MRM

Current status of MRM

Although MRI is very common for medical applications, MRM is still developing in laboratories up to resonance frequencies of 1000 MHz[1] (for nuclear magnetic resonance; electron magnetic resonance commonly operates at much higher frequencies). The major barriers for practical MRM include:

Alternative MRM

Magnetic Resonance Force Microscopy (MRFM) has nm³-scale resolution. It improves the sensitivity issue by introducing microfabricated cantilevers to measure tiny signals. The magnetic gradient is generated by a micrometre-scale magnetic tip, yielding a typical gradient 10 million times larger than those of clinical systems. This technique is still in the early phase of development. Because the specimen needs to be in a high vacuum at cryogenic temperatures, MRFM can be used only for solid state materials.

References

  1. R. Sharma, Microimaging of hairless rat skin by magnetic resonance at 900 MHz. Magnetic Resonance Imaging. 27(2):240-255, 2009
  2. P. Glover and P. Mansfield, Limits to magnetic resonance microscopy, Rep. Prog. Phys. 65 1489–1511, 2002
  3. R. Sharma, A. Sharma. 21.1 Tesla Magnetic Resonance Imaging Apparatus and Image Interpretation: First Report of a Scientific Advancement. Recent Patents in Medical Imaging.1(2):89-104, 2011
  4. R. Sharma, B.R. Locke. Jet Fuel Toxicity: Skin Damage measured by 900 MHz MRI Skin Microscopy and Visualization by 3D MRI Image Processing. Magn Reson Imaging.30(1):1013-1048, 2010
  5. R. Maronpot. Applications of Magnetic Resonance Microscopy, Toxicologic Pathology, 32(Suppl. 2):42–48, 2004
  6. R. Sharma,Physical Basis of Gadolinium Induced Skin Nephrofibrosis: Testing by Gadolinium-Protein Targeting Assay and Iron Oxide Nanoparticle Based Magnetic Resonance Microscopy. ISRN Dermatology. 1;---

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External links

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