Mainframe (disambiguation)
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Mainframe may refer to any of the following:
- Mainframe computer, a type of large data processing system
- Mainframe Entertainment, a computer animation company
- Either of two fictional Marvel Comics characters:
- Mainframe (comics), from the series A-Next
- Mainframe, a character from the Guardians of the Galaxy series
- Mainframe (Transformers), a character in the Transformers series
- Mainframe (G.I. Joe), a character in the G.I. Joe universe
- A character from the game Gunman Chronicles
- Mainframe, the city in which the animated series ReBoot takes place
- A character in Gene Wolfe's novel/series The Book of the Long Sun
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