Major histocompatibility complex, class I-related

Major histocompatibility complex, class I-related
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4GUP​, 4L4T​, 4L4V​, 4LCW​, 4NQC​, 4NQD​, 4NQE​, 4PJ5​, 4PJ7​, 4PJ8​, 4PJ9​, 4PJA​, 4PJB​, 4PJC​, 4PJD​, 4PJE​, 4PJF​, 4PJG​, 4PJH​, 4PJI​, 4PJX​
Identifiers
Symbols	MR1 ; HLALS
External IDs	OMIM: 600764 MGI: 1195463 HomoloGene: 123981 GeneCards: MR1 Gene
Gene ontology Molecular function • protein binding • MHC class I receptor activity • peptide antigen binding Cellular component • extracellular region • endoplasmic reticulum • endoplasmic reticulum membrane • plasma membrane • integral component of membrane • MHC class I protein complex Biological process • cytokine production involved in immune response • antigen processing and presentation of peptide antigen via MHC class I • immune response • signal transduction • interleukin-1 beta production • interleukin-17 production • innate immune response • defense response to Gram-negative bacterium Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3140	15064
Ensembl	ENSG00000153029	ENSMUSG00000026471
UniProt	Q95460	Q8HWB0
RefSeq (mRNA)	NM_001194999	NM_008209
RefSeq (protein)	NP_001181928	NP_032235
Location (UCSC)	Chr 1: 181.03 – 181.06 Mb	Chr 1: 155.13 – 155.15 Mb
PubMed search

Major histocompatibility complex class I-related gene protein is a protein that in humans is encoded by the MR1 gene.^[1][2][3]

References

1. Hashimoto K, Hirai M, Kurosawa Y (Aug 1995). "A gene outside the human MHC related to classical HLA class I genes". Science 269 (5224): 693–5. doi:10.1126/science.7624800. PMID 7624800.
2. Yamaguchi H, Kurosawa Y, Hashimoto K (Nov 1998). "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog". Biochem Biophys Res Commun 250 (3): 558–64. doi:10.1006/bbrc.1998.9353. PMID 9784382.
3. "Entrez Gene: MR1 major histocompatibility complex, class I-related".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Yamaguchi H, Hirai M, Kurosawa Y, Hashimoto K (1997). "A highly conserved major histocompatibility complex class I-related gene in mammals.". Biochem. Biophys. Res. Commun. 238 (3): 697–702. doi:10.1006/bbrc.1997.7379. PMID 9325151.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Riegert P, Wanner V, Bahram S (1998). "Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene.". J. Immunol. 161 (8): 4066–77. PMID 9780177.
• Parra-Cuadrado JF, Navarro P, Mirones I, et al. (2001). "A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene.". Tissue Antigens 56 (2): 170–2. doi:10.1034/j.1399-0039.2000.560211.x. PMID 11019920.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Miley MJ, Truscott SM, Yu YY, et al. (2003). "Biochemical features of the MHC-related protein 1 consistent with an immunological function.". J. Immunol. 170 (12): 6090–8. doi:10.4049/jimmunol.170.12.6090. PMID 12794138.
• Hempelmann A, Kumar S, Muralitharan S, Sander T (2007). "Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia.". Neurosci. Lett. 402 (1-2): 118–20. doi:10.1016/j.neulet.2006.03.048. PMID 16632198.