Malonyl CoA reductase (malonate semialdehyde-forming)

Malonyl CoA reductase (malonate semialdehyde-forming) (EC 1.2.1.75, NADP-dependent malonyl CoA reductase, malonyl CoA reductase (NADP)) is an enzyme with systematic name malonate semialdehyde:NADP⁺ oxidoreductase (malonate semialdehyde-forming).^[1]^[2]^[3]^[4] This enzyme catalyse the following chemical reaction

malonate semialdehyde + CoA + NADP⁺

\rightleftharpoons

malonyl-CoA + NADPH + H⁺

Requires Mg²⁺. Catalyses the reduction of malonyl-CoA to malonate semialdehyde.

References

↑ Strauss, G. and Fuchs, G. (1993). "Enzymes of a novel autotrophic CO₂ fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle". Eur. J. Biochem. 215: 633–643. doi:10.1111/j.1432-1033.1993.tb18074.x. PMID 8354269.
↑ Berg, I.A., Kockelkorn, D., Buckel, W. and Fuchs, G. (2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science 318: 1782–1786. doi:10.1126/science.1149976. PMID 18079405.
↑ Alber, B., Olinger, M., Rieder, A., Kockelkorn, D., Jobst, B., Hugler, M. and Fuchs, G. (2006). "Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp". J. Bacteriol. 188 (24): 8551–8559. doi:10.1128/JB.00987-06. PMC 1698253. PMID 17041055.
↑ Hugler, M., Menendez, C., Schagger, H. and Fuchs, G. (2002). "Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO₂ fixation". J. Bacteriol. 184 (9): 2404–2410. doi:10.1128/jb.184.9.2404-2410.2002. PMC 134993. PMID 11948153.

External links

Malonyl CoA reductase (malonate semialdehyde-forming) at the US National Library of Medicine Medical Subject Headings (MeSH)

Aldehyde/oxo oxidoreductases (EC 1.2)

1.2.1: NAD or NADP	Aldehyde dehydrogenase Acetaldehyde dehydrogenase Long-chain-aldehyde dehydrogenase

1.2.2: cytochrome	Formate dehydrogenase (cytochrome)

1.2.3: oxygen	Aldehyde oxidase

1.2.4: disulfide	Oxoglutarate dehydrogenase complex Pyruvate dehydrogenase Branched-chain alpha-keto acid dehydrogenase complex BCKDHA BCKDHB DBT DLD

1.2.7: iron-sulfur protein	Pyruvate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

This article is issued from Wikipedia - version of the Wednesday, March 30, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.