Mammaglobin-A

Secretoglobin, family 2A, member 2
Identifiers
Symbols	SCGB2A2 ; MGB1; UGB2
External IDs	OMIM: 605562 HomoloGene: 82995 GeneCards: SCGB2A2 Gene
Gene ontology Molecular function • molecular_function • protein binding Cellular component • cellular_component Biological process • biological_process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4250	n/a
Ensembl	ENSG00000110484	n/a
UniProt	Q13296	n/a
RefSeq (mRNA)	NM_002411	n/a
RefSeq (protein)	NP_002402	n/a
Location (UCSC)	Chr 11: 62.27 – 62.27 Mb	n/a
PubMed search		n/a

Mammaglobin-A also known as secretoglobin family 2A member 2 is a protein that in humans is encoded by the SCGB2A2 gene.^[1][2][3]

Function

SCGB2A2 is a member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seem to be involved in cell signalling, immune response, and chemotaxis, and may also serve as transporters for steroid hormones in humans.^[4][5]

Clinical significance

SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells.^[6]

References

1. Watson MA, Darrow C, Zimonjic DB, Popescu NC, Fleming TP (Mar 1998). "Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13". Oncogene 16 (6): 817–24. doi:10.1038/sj.onc.1201597. PMID 9488047.
2. Watson MA, Fleming TP (Jul 1996). "Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer". Cancer Res 56 (4): 860–5. PMID 8631025.
3. "Entrez Gene: SCGB2A2 secretoglobin, family 2A, member 2".
4. Klug J, Beier HM, Bernard A, Chilton BS, Fleming TP, Lehrer RI, Miele L, Pattabiraman N, Singh G (2000). "Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report". Annals of the New York Academy of Sciences 923: 348–354. doi:10.1111/j.1749-6632.2000.tb05549.x. PMID 11193777.
5. Brown NM, Stenzel TT, Friedman PN, Henslee J, Huper G, Marks JR (2006). "Evaluation of expression based markers for the detection of breast cancer cells". Breast Cancer Research and Treatment 97 (1): 41–47. doi:10.1007/s10549-005-9085-8. PMID 16319979.
6. Lacroix M (2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer (Bioscientifica) 13 (4): 1033–1067. doi:10.1677/ERC-06-0001. PMID 17158753.

Further reading

• Wilson PC, de Bouteiller O, Liu YJ, Potter K, Banchereau J, Capra JD, Pascual V (1998). "Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.". J. Exp. Med. 187 (1): 59–70. doi:10.1084/jem.187.1.59. PMC 2199186. PMID 9419211.
• Fischer M, Küppers R (1998). "Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes.". Eur. J. Immunol. 28 (9): 2971–7. doi:10.1002/(SICI)1521-4141(199809)28:09<2971::AID-IMMU2971>3.0.CO;2-3. PMID 9754584.
• Carter D, Douglass JF, Cornellison CD, Retter MW, Johnson JC, Bennington AA, Fleming TP, Reed SG, Houghton RL, Diamond DL, Vedvick TS (2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer.". Biochemistry 41 (21): 6714–22. doi:10.1021/bi0159884. PMID 12022875.
• Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
• Cerveira N, Torres L, Rocha P, Bizarro S, Pereira D, Abreu J, Henrique R, Teixeira MR, Castedo S (2004). "Highly sensitive detection of the MGB1 transcript (mammaglobin) in the peripheral blood of breast cancer patients.". Int. J. Cancer 108 (4): 592–5. doi:10.1002/ijc.11609. PMID 14696125.
• Ouellette RJ, Richard D, Maïcas E (2004). "RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes.". Am. J. Clin. Pathol. 121 (5): 637–43. doi:10.1309/MMAC-TXT5-5L8Q-TKC1. PMID 15151203.
• Ferrucci PF, Rabascio C, Mazzetta C, Cocorocchio E, Agazzi A, Vanazzi A, Cinieri S, Peccatori FA, Paolucci M, Bertolini F, Martinelli G (2005). "Mammaglobin expression in leukapheresis products is a predictive marker of poor prognosis in women with high-risk breast cancer.". Clin. Cancer Res. 10 (18 Pt 1): 6039–46. doi:10.1158/1078-0432.CCR-03-0453. PMID 15447988.
• O'Brien NA, O'Donovan N, Ryan B, Hill AD, McDermott E, O'Higgins N, Duffy MJ (2005). "Mammaglobin a in breast cancer: existence of multiple molecular forms.". Int. J. Cancer 114 (4): 623–7. doi:10.1002/ijc.20780. PMID 15609337.
• Roncella S, Ferro P, Bacigalupo B, Pronzato P, Tognoni A, Falco E, Gianquinto D, Ansaldo V, Dessanti P, Fais F, Rosai J, Fedeli F (2005). "Human mammaglobin mRNA is a reliable molecular marker for detecting occult breast cancer cells in peripheral blood.". J. Exp. Clin. Cancer Res. 24 (2): 265–71. PMID 16110760.
• Span PN, Sweep FC (2006). "Mammaglobin as molecular marker of breast cancer (micro)metastases.". Clin. Cancer Res. 11 (19 Pt 1): 7043; author reply 7044. doi:10.1158/1078-0432.CCR-05-1378. PMID 16203799.
• Roncella S, Ferro P, Bacigalupo B, Dessanti P, Giannico A, Gorji N, Moroni M, Tozzini S, Pensa F, Gianquinto D, Fais F, Pronzato P, Fedeli F (2006). "Relationship between human mammaglobin mRNA expression in breast cancer tissue and clinico-pathologic features of the tumors.". J. Exp. Clin. Cancer Res. 25 (1): 65–72. PMID 16761620.
• Ntoulia M, Stathopoulou A, Ignatiadis M, Malamos N, Mavroudis D, Georgoulias V, Lianidou ES (2007). "Detection of Mammaglobin A-mRNA-positive circulating tumor cells in peripheral blood of patients with operable breast cancer with nested RT-PCR.". Clin. Biochem. 39 (9): 879–87. doi:10.1016/j.clinbiochem.2006.06.009. PMID 16925986.
• Gimbergues P, Dauplat MM, Cayre A, Durando X, Le Bouedec G, Finat-Duclos F, Portefaix G, Kwiatkowski F, Dauplat J, Penault-Llorca F, Tchirkov A (2007). "Correlation between molecular metastases in sentinel lymph nodes of breast cancer patients and St Gallen risk category.". Eur J Surg Oncol 33 (1): 16–22. doi:10.1016/j.ejso.2006.09.013. PMID 17071045.
• Sasaki E, Tsunoda N, Hatanaka Y, Mori N, Iwata H, Yatabe Y (2007). "Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers.". Mod. Pathol. 20 (2): 208–14. doi:10.1038/modpathol.3800731. PMID 17192791.