Manganese exporter
| Putative Manganese Efflux Pump | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | MntP | ||||||||
| Pfam | PF02659 | ||||||||
| InterPro | IPR003810 | ||||||||
| |||||||||
The Manganese (Mn2+) Exporter (MntP) Family (TC# 2.A.107) is a member of the Lysine Exporter (LysE) Superfamily.[1] The MntP family is a small family whose members have been found in bacteria and archaea. MntP proteins are of about 200 amino acyl residues with 6 putative transmembrane segments (TMSs). The Conserved Domain Database (CDD) recognized two DUF204 repeats, each repeat having 3 TMSs. A representative list of proteins belonging to the MntP family can be found in the Transporter Classification Database.
Function
At least one member (YebN of E. coli, TC# 2.A.107.1.1) has been shown to function as a putative manganese efflux pump. Manganese sensitivity and intracellular manganese levels significantly increased in bacteria when the mntP (formerly yebN) gene, which encodes the MntP efflux pump, was deleted. While manganese is a highly important trace nutrient for organisms from bacteria to humans, acting as an important element in the defense against oxidative stress and as an enzyme cofactor, it becomes toxic when present in excess.[2]
See Also
Further Reading
- Martin, Julia E.; Waters, Lauren S.; Storz, Gisela; Imlay, James A. (2015-03-01). "The Escherichia coli small protein MntS and exporter MntP optimize the intracellular concentration of manganese". PLoS genetics 11 (3): e1004977. doi:10.1371/journal.pgen.1004977. ISSN 1553-7404. PMC 4361602. PMID 25774656.
- Farcasanu, Ileana C.; Hirata, Dai; Tsuchiya, Eiko; Nishiyama, Fumitaka; Miyakawa, Tokichi (1995-09-01). "Protein Phosphatase 2B of Saccharomyces Cerevisiae is Required for Tolerance to Manganese, in Blocking the Entry of ions into the Cells". European Journal of Biochemistry 232 (3): 712–717. doi:10.1111/j.1432-1033.1995.712zz.x. ISSN 1432-1033.
- Jensen, Amornrat Naranuntarat; Jensen, Laran T. (2015-01-01). CHAPTER 1. Manganese Transport, Trafficking and Function in Invertebrates. Royal Society of Chemistry. pp. 1–33. doi:10.1039/9781782622383-00001.
References
- ↑ Tsu, Brian V.; Saier, Milton H. (2015-01-01). "The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis". PloS One 10 (10): e0137184. doi:10.1371/journal.pone.0137184. ISSN 1932-6203. PMC 4608589. PMID 26474485.
- ↑ Waters, Lauren S.; Sandoval, Melissa; Storz, Gisela (2011-11-01). "The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis". Journal of Bacteriology 193 (21): 5887–5897. doi:10.1128/JB.05872-11. ISSN 1098-5530. PMC 3194919. PMID 21908668.