Manju Ray
| Manju Ray | |
|---|---|
| Alma mater | Calcutta University, |
| Occupation | Emeritus Scientist |
| Religion | Hindu |
Manju Ray is an Indian scientist in Molecular Enzymology and Cancer Biochemistry. She has done notable work in the development of anticancer drug and understanding of differentiation process of cells.[1] Her interests cover tumor biochemistry and molecular enzymology.[2]
Biography
Ray graduated from the Calcutta University with degrees in M.Sc. in Physiology in 1969 and Ph.D in Biochemistry in 1975. She started her career in the Department of Biochemistry, Indian Association of Cultivation of Science and became a professor. She is an Emeritus Scientist at the Bose Institute of the Council of Scientific and Industrial Research (CSIR).[2] Her research has, over a long span of her career in the department of biochemistry at the Indian Association for the Cultivation of Science (IACS), Jadavpur, in association with a team of scintists and doctor has led to positive development of a drug for cancer treatment[3] At the Bose Institute she carried out a research project on animal toxicology and treatment of cancer patients by a unique anticancer formula with methylglyoxal as main compound. The drug was tested on patients in three groups, the first group consisted of 24 patients who were subjected to tests for 14 months, the second group of 40 patients were subject to tests over a period of 60 months, and the third group consisted of 23 patients during a period lasting 42 months. The parameters tested were biochemical, radiological and other treatments to evaluate the likely toxicity of methylglyoxal on a long term basis; results showed no toxicity thus holding a positive reaction to methylglyoxal treatment which however was subject further improvements.[4]
Awards
Ray received Indian National Science Academy (INSA) Young Scientist Medal in Biological Science in 1975 and the Shanti Swarup Bhatnagar Prize for Science and Technology Shanti Swarup Bhatnagar Prize in Biological Science in 1989.[1]
Publications
Ray has published a large number of scientific papers as lead author in association with others and some of which are:
- Inhibition of respiration of tumor cells by methyl glyoxal and protection of inhibition by lactaldehyde (1991) in International Journal of Cancer
- Inhibition of electron flow through complex I of the mitochondrial respiratory chain on Earlich Ascites Carsinoma cells by methyl Glyoxal (1994) in Biochemical Journal
- Glyoxalase III from Escherichia coli a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione (1995) in Biochemical Journal
- Methylglyoxal : From a putative intermediate of glucose breakdown to its role in understanding that excessive ATP formation in cells may lead to malignancy (1998) in Current Science
- Glyceraldehyde-3-phosphate dehydrogenase from Earlich Ascites Carcinoma cells: its possible role in the high glycolysis of malignant cells (1999) in European Journal of Biochemistry
References
- 1 2 "Manju Ray". Indian Association for the Cultivation of Science. Retrieved 1 November 2015.
- 1 2 Dutta, Kausik (25 October 2013). "Noted Women Scientists of India – an attempt at enumeration". SciLogs. Retrieved 1 November 2015.
- ↑ Ukil, Amit. "Hope For Cancer Patients In Calcutta Team’s Drug Trials". The Telegraph, India. Retrieved 1 November 2015.
- ↑ "Manju Ray". 4th World Congress on Cancer Science and Therapy. October 2014. Retrieved 1 November 2015.