Martin Kreitman

Professor Martin Kreitman
Born	Martin Edward Kreitman
Institutions	University of Chicago Harvard University Stony Brook University University of Florida
Alma mater	Harvard University (PhD) University of Florida Stony Brook University (undergraduate)
Thesis	Nucleotide Sequence Variation of Alcohol dehydrogenase in Drosophila melanogaster (1983)
Doctoral advisor	Richard Lewontin[1][2]
Doctoral students	Hiroshi Akashi[3] Eli Stahl[3] Peter Andolfatto Casey Bergman[4] Andrew Crawford Bin He Mark Allen Jensen Fengli Liu Susan Lott Stephanie Rollmann
Known for	McDonald–Kreitman test
Notable awards	MacArthur Fellows Program (1991)
Website pondside.uchicago.edu/ecol-evol/people/kreitman.html

Professor Martin Edward Kreitman is an American geneticist at the University of Chicago,^[5][6][7] most well known for the McDonald–Kreitman test that is used to infer the amount of adaptive evolution in population genetic studies.

Education

Kreitman graduated from Stony Brook University with a Bachelor of Science degree Biology in 1975, and from the University of Florida with a Master of Science degree in Zoology, in 1977. He went on to study at Harvard University, graduating with a Ph.D. in Population Genetics, specifically Nucleotide Sequence Variation of Alcohol dehydrogenase in Drosophila melanogaster^[8] in 1983.^[9]

Research

The Kreitman lab does research in four main areas:^{[10][11][12][13]}

"Functional evolution of cis-regulatory sequences (Drosophila)"^[14]

"Molecular population genetics and evolution (Drosophila and Arabidopsis)"^[14]

"Canalization in development and evolution (Drosophila)"^[14]

"Evolutionary dynamics of disease resistance and pathogenicity (Arabidopsis)"^[14]

Awards and honors

• 1991 MacArthur Fellows Program
• editor-in-chief of "Journal of Molecular Evolution" from 1999
• Section head of the "Evolutionary/Comparative Genetics" part of Faculty of 1000 biology ^[15]
• 2010 named fellow of the American Academy of Arts and Sciences ^[16]

Recent Publications

• Ludwig, M. Z.; Manu; Kittler, R.; White, K. P.; Kreitman, M. (2011). Malik, Harmit S, ed. "Consequences of Eukaryotic Enhancer Architecture for Gene Expression Dynamics, Development, and Fitness". PLoS Genetics 7 (11): e1002364. doi:10.1371/journal.pgen.1002364. PMC 3213169. PMID 22102826.
• He, B. Z.; Holloway, A. K.; Maerkl, S. J.; Kreitman, M. (2011). Petrov, Dmitri A, ed. "Does Positive Selection Drive Transcription Factor Binding Site Turnover? A Test with Drosophila Cis-Regulatory Modules". PLoS Genetics 7 (4): e1002053. doi:10.1371/journal.pgen.1002053. PMC 3084208. PMID 21572512.
• Lott, S. E.; Ludwig, M. Z.; Kreitman, M. (2011). "Evolution and Inheritance of Early Embryonic Patterning in Drosophila Simulans and D. Sechellia". Evolution 65 (5): 1388–1399. doi:10.1111/j.1558-5646.2010.01206.x. PMC 3083464. PMID 21121913.
• Bakker, E. G.; Traw, M. B.; Toomajian, C.; Kreitman, M.; Bergelson, J. (2008). "Low Levels of Polymorphism in Genes That Control the Activation of Defense Response in Arabidopsis thaliana". Genetics 178 (4): 2031–2043. doi:10.1534/genetics.107.083279. PMC 2323794. PMID 18245336.
• Araki, H.; Innan, H.; Kreitman, M.; Bergelson, J. (2007). "Molecular Evolution of Pathogenicity-Island Genes in Pseudomonas viridiflava". Genetics 177 (2): 1031–1041. doi:10.1534/genetics.107.077925. PMC 2034611. PMID 17720907.
• Lott, S. E.; Kreitman, M.; Palsson, A.; Alekseeva, E.; Ludwig, M. Z. (2007). "Canalization of segmentation and its evolution in Drosophila". Proceedings of the National Academy of Sciences 104 (26): 10926–10931. doi:10.1073/pnas.0701359104. PMC 1891814. PMID 17569783.
• Bakker, E. G. (2006). "A Genome-Wide Survey of R Gene Polymorphisms in Arabidopsis". The Plant Cell Online 18 (8): 1803–1818. doi:10.1105/tpc.106.042614.
• Bakker, E. G.; Stahl, E. A.; Toomajian, C.; Nordborg, M.; Kreitman, M.; Bergelson, J. (2006). "Distribution of genetic variation within and among local populations of Arabidopsis thaliana over its species range". Molecular Ecology 15 (5): 1405–1418. doi:10.1111/j.1365-294X.2006.02884.x. PMID 16626462.
• Araki, H. (2006). "Presence/absence polymorphism for alternative pathogenicity islands in Pseudomonas viridiflava, a pathogen of Arabidopsis". Proceedings of the National Academy of Sciences 103 (15): 5887–5810. doi:10.1073/pnas.0601431103.
• Nordborg, M.; Hu, T. T.; Ishino, Y.; Jhaveri, J.; Toomajian, C.; Zheng, H.; Bakker, E.; Calabrese, P.; Gladstone, J.; Goyal, R.; Jakobsson, M.; Kim, S.; Morozov, Y.; Padhukasahasram, B.; Plagnol, V.; Rosenberg, N. A.; Shah, C.; Wall, J. D.; Wang, J.; Zhao, K.; Kalbfleisch, T.; Schulz, V.; Kreitman, M.; Bergelson, J. (2005). "The Pattern of Polymorphism in Arabidopsis thaliana". PLoS Biology 3 (7): e196. doi:10.1371/journal.pbio.0030196. PMC 1135296. PMID 15907155.
• Ludwig, M. Z.; Palsson, A.; Alekseeva, E.; Bergman, C. M.; Nathan, J.; Kreitman, M. (2005). "Functional Evolution of a cis-Regulatory Module". PLoS Biology 3 (4): e93. doi:10.1371/journal.pbio.0030093. PMC 1064851. PMID 15757364.
• Kreitman, M.; Di Rienzo, A. (2004). "Balancing claims for balancing selection". Trends in Genetics 20 (7): 300–304. doi:10.1016/j.tig.2004.05.002. PMID 15219394.
• Goss, E. M.; Kreitman, M.; Bergelson, J. (2004). "Genetic Diversity, Recombination and Cryptic Clades in Pseudomonas viridiflava Infecting Natural Populations of Arabidopsis thaliana". Genetics 169 (1): 21–35. doi:10.1534/genetics.104.031351. PMC 1448860. PMID 15489535.
• Mauricio, R.; Stahl, E. A.; Korves, T.; Tian, D.; Kreitman, M.; Bergelson, J. (2003). "Natural selection for polymorphism in the disease resistance gene Rps2 of Arabidopsis thaliana". Genetics 163 (2): 735–746. PMC 1462445. PMID 12618410.
• Tian, D.; Traw, M. B.; Chen, J. Q.; Kreitman, M.; Bergelson, J. (2003). "Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana". Nature 423 (6935): 74–77. doi:10.1038/nature01588. PMID 12721627.
• Toomajian, C.; Ajioka, R. S.; Jorde, L. B.; Kushner, J. P.; Kreitman, M. (2003). "A method for detecting recent selection in the human genome from allele age estimates". Genetics 165 (1): 287–297. PMC 1462736. PMID 14504236.
• Tian, D. (2002). "Signature of balancing selection in Arabidopsis". Proceedings of the National Academy of Sciences 99 (17): 11525–11530. doi:10.1073/pnas.172203599.
• Toomajian, C.; Kreitman, M. (2002). "Sequence variation and haplotype structure at the human HFE locus". Genetics 161 (4): 1609–1623. PMC 1462210. PMID 12196404.
• Jakob, K.; Goss, E. M.; Araki, H.; Van, T.; Kreitman, M.; Bergelson, J. (2002). "Pseudomonas viridiflavaandP. Syringae—Natural Pathogens ofArabidopsis thaliana". Molecular Plant-Microbe Interactions 15 (12): 1195–1203. doi:10.1094/MPMI.2002.15.12.1195. PMID 12481991.
• Comeron, J. M.; Kreitman, M. (2002). "Population, evolutionary and genomic consequences of interference selection". Genetics 161 (1): 389–410. PMC 1462104. PMID 12019253.
• Nordborg, M.; Borevitz, J. O.; Bergelson, J.; Berry, C. C.; Chory, J.; Hagenblad, J.; Kreitman, M.; Maloof, J. N.; Noyes, T.; Oefner, P. J.; Stahl, E. A.; Weigel, D. (2002). "The extent of linkage disequilibrium in Arabidopsis thaliana". Nature Genetics 30 (2): 190–193. doi:10.1038/ng813. PMID 11780140.
• Bergman, C. M.; Kreitman, M. (2001). "Analysis of Conserved Noncoding DNA in Drosophila Reveals Similar Constraints in Intergenic and Intronic Sequences". Genome Research 11 (8): 1335–1345. doi:10.1101/gr.178701. PMID 11483574.
• Bergelson, J.; Kreitman, M.; Stahl, E. A.; Tian, D. (2001). "Evolutionary Dynamics of Plant R-Genes". Science 292 (5525): 2281–2285. doi:10.1126/science.1061337. PMID 11423651.
• Comeron, J. M.; Kreitman, M. (2000). "The correlation between intron length and recombination in drosophila. Dynamic equilibrium between mutational and selective forces". Genetics 156 (3): 1175–1190. PMC 1461334. PMID 11063693.
• Ludwig, M. Z.; Bergman, C.; Patel, N. H.; Kreitman, M. (2000). "Evidence for stabilizing selection in a eukaryotic enhancer element". Nature 403 (6769): 564–567. doi:10.1038/35000615. PMID 10676967.
• Bergelson, J.; Stahl, E. A.; Dwyer, G.; Mauricio, R.; Kreitman, M. (1999). "Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis". Nature 400 (6745): 667–671. doi:10.1038/23260. PMID 10458161.
• Comeron, J. M.; Kreitman, M.; Aguadé, M. (1999). "Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila". Genetics 151 (1): 239–249. PMC 1460462. PMID 9872963.
• Ludwig, M. Z.; Patel, N. H.; Kreitman, M. (1998). "Functional analysis of eve stripe 2 enhancer evolution in Drosophila: Rules governing conservation and change". Development (Cambridge, England) 125 (5): 949–958. PMID 9449677.

References

1. "On the 30th Anniversary of DNA Sequencing in Population Genetics | I wish you'd made me angry earlier". Archived from the original on 2013-08-06.
2. Keith, T. P.; Riley, M. A.; Kreitman, M.; Lewontin, R. C.; Curtis, D.; Chambers, G. (1987). "Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster". Genetics 116 (1): 67–73. PMC 1203122. PMID 3036646.
3. "Alumni | Ecology & Evolution | University of Chicago". Archived from the original on 2013-08-07.
4. Bergman, Casey M. (2001). Evolutionary analyses of transcriptional control sequences in Drosophila (PhD thesis). University of Chicago.
5. http://pondside.uchicago.edu/ecol-evol/people/kreitman.html
6. http://arrafunding.uchicago.edu/investigators/kreitman_m.shtml
7. Martin Kreitman's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
8. Kreitman, Martin Edward (1983). Nucleotide Sequence Variation of Alcohol dehydrogenase in Drosophila melanogaster (PhD thesis). Harvard University.
9. http://molbio.bsd.uchicago.edu/Faculty_and_Research/01_Faculty_Alphabetically.php?faculty_id=88
10. Kreitman, M. (1983). "Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster". Nature 304 (5925): 412–417. doi:10.1038/304412a0. PMID 6410283.
11. McDonald, J. H.; Kreitman, Martin (1991). "Adaptive protein evolution at the Adh locus in Drosophila". Nature 351 (6328): 652–654. doi:10.1038/351652a0. PMID 1904993.
12. Hudson, R. R.; Kreitman, M.; Aguadé, M. (1987). "A test of neutral molecular evolution based on nucleotide data". Genetics 116 (1): 153–159. PMC 1203113. PMID 3110004.
13. Kreitman, Martin (2000). "Methods to detect selection In populations with applications to the human". Annual Review of Genomics and Human Genetics 1: 539–559. doi:10.1146/annurev.genom.1.1.539. PMID 11701640.
14. "Faculty | Ecology & Evolution | University of Chicago". Archived from the original on 2013-08-06.
15. http://f1000biology.com/about/members/8008
16. http://www.igsb.org/news/martin-kreitman-named-fellow-of-the-american-academy-of-arts-and-sciences/

External links

• "Martin Kreitman", Scientific Commons