Matriptase

Matriptase
Identifiers
EC number	3.4.21.109
CAS number	241475-96-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Matriptase (EC 3.4.21.109, serine protease 14, membrane-type serine protease 1, MT-SP1, prostamin, serine protease TADG-15, tumor-associated differentially-expressed gene 15 protein, ST14, breast cancer 80 kDa protease, epithin, serine endopeptidase SNC19) is an enzyme.^[1][2] This enzyme catalyses the following chemical reaction

Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position

This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis.

References

1. Lee, S.L., Dickson, R.B. and Lin, C.Y. (2000). "Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease". J. Biol. Chem. 275: 36720–36725. doi:10.1074/jbc.M007802200. PMID 10962009.
2. Lin, C.Y., Anders, J., Johnson, M., Sang, Q.A. and Dickson, R.B. (1999). "Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity". J. Biol. Chem. 274: 18231–18236. doi:10.1074/jbc.274.26.18231. PMID 10373424.

External links

• Matriptase at the US National Library of Medicine Medical Subject Headings (MeSH)