Maureen Murphy (scientist)

Maureen E. Murphy, Ph.D., is a researcher at The Wistar Institute in Philadelphia.^[1][2][3] Her research focuses on the tumor suppressor genes p53 and p14arf.

Murphy's research on p53 has indicated that the gene is able to suppress tumors by inducing apoptosis in cells where DNA damage has occurred. She has focused in particular on various polymorphisms that might impact the ability of p53 to suppress tumors. Murphy's research has shown that certain variants are more common in certain ethnic groups, providing a possible explanation as to why certain types of cancer affect certain populations.^[4][5]

Murphy serves on the international committee of the International p53 Workshop^[6] and served as co-chair of the workshop in 2010.^[7]

Select publications

• Azzam GA, Wang X, Bell DA and Murphy ME. CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest. PLoS One, in press.

• Budina-Kolomets A, Hontz RD, Pimkina J, Murphy ME. A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction. Autophagy 2013; Aug 7;9(10).

• Murphy ME. The HSP70 family and cancer. Carcinogenesis 2013; 34(6):1181-8.

• Balaburski GM, Leu JI, Beeharry N, Hayik S, Andrake MD, Zhang G, Herlyn M, Villanueva J, Dunbrack RL Jr, Yen T, George DL, Murphy ME. A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res 2013;11(3):219-29.

• Leu JI, Pimkina J, Pandey P, Murphy ME, George DL. HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Mol Cancer Res. 2011; 9:936-47.

References

1. "Maureen Murphy, Ph.D.". The Wistar Institute. Retrieved 18 February 2014.
2. "Maureen E. Murphy, Ph.D.". Perelman School of Medicine. Retrieved 18 February 2014.
3. "Fox Chase professor leaving for Wistar". Philadelphia Business Journal. Retrieved 18 February 2014.
4. "p53 may affect susceptibility to cancer and other diseases". National Institute of Environmental Health Sciences. Retrieved 18 February 2014.
5. "Common variant of p53 tumor suppressor gene linked to increased inflammatory responses". ScienceDaily. Retrieved 18 February 2014.
6. "Committees". 16th International p53 Workshop. Retrieved 18 February 2014.
7. "The 15th International p53 Workshop will be held October 8-12, 2010 in Philadelphia at the University of Pennsylvania School of Medicine.". Abramson Cancer Center. Retrieved 18 February 2014.

External links

• Dr. Murphy's lab page on The Wistar Institute's website