Maytansinoid
A maytansinoid is a chemical derivative of maytansine.[1]
Some are being investigated as the cytotoxic component of antibody-drug conjugates.[1] Anticancer properties of maytansinoids have been attributed to their ability to disrupt microtubule function. The maytaninoid emtansine (DM1), for example, binds at the ends of microtubules and thereby suppress their dynamic instability[2]
Examples:
- Ansamitocin[3]
- Mertansine/emtansine (DM1)
- ravtansine/soravtansine (DM4)
See also
- ImmunoGen Inc, developer of maytansinoid based drugs.
References
- 1 2 "Immunoconjugates containing novel maytansinoids: promising anticancer drugs." (PDF). Cancer Res. 52: 127–31. January 1992. PMID 1727373.
- ↑ Lopus, M; Oroudjev, E; Wilson, L; Wilhelm, S; Widdison, W; Chari, R; Jordan, MA (2010). "Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules". Mol Cancer Ther 9: 2689–99. doi:10.1158/1535-7163.MCT-10-0644. PMID 20937594.
- ↑ "The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnemapretiosum". Proc. Natl. Acad. Sci. U.S.A. 99: 7968–73. June 2002. doi:10.1073/pnas.092697199. PMC 123004. PMID 12060743.
This article is issued from Wikipedia - version of the Saturday, March 05, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.