mdx mouse

The mdx mouse is a popular model for studying Duchenne muscular dystrophy (DMD).

The mdx mouse has a point mutation in its DMD gene, changing the amino acid coding for a glutamine to a threonine. This causes the muscle cells to produce a small, nonfunctional dystrophin protein.[1] As a result, the mouse has a mild form of DMD where there increased muscle damage and weakness.

References

  1. ↑ "Animal Models - Parent Project Muscular Dystrophy". www.parentprojectmd.org. Retrieved 2016-05-03.


This article is issued from Wikipedia - version of the Wednesday, May 04, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.