Memapsin 1

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Memapsin 1 (EC 3.4.23.45, beta-secretase, beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2 (BACE2), ASP1, Down region aspartic protease) is an enzyme.^[1] This enzyme catalyses the following chemical reaction

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein

This enzyme belongs to the peptidase family A1.

References

↑ Turner, R.T., Loy, J.A., Nguyen, C., Devasamudram, T., Ghosh, A.K., Koelsch, G. and Tang, J. (2002). "Specificity of memapsin 1 and its implications on the design of memapsin 2 (β-secretase) inhibitor selectivity". Biochemistry 41: 8742–8746. doi:10.1021/bi025926t. PMID 12093293.

External links

Memapsin 1 at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: aspartate proteases (EC 3.4.23)

Vertebrate	Pepsin Chymosin Renin Signal peptide peptidase Beta secretase 1 2

Pathogenic	Plasmepsin HIV-1 protease

Plant	Nepenthesin

Cathepsin	D E

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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