Metabolic trapping

Metabolic trapping is a localization mechanism of the synthesized radiocompounds in human body. It can be defined as intracellular accumulation of a drug or radioactive probe depending on metabolic activity of respective tissue. [1]Metabolic trapping is a principle in the design of radiopharmaceuticals as metabolic probes for function or tumor location.[2]

References

  1. ↑ J.S. Fowler et al. Methods 27 (2002) 263–27
  2. ↑ . Gallagher,Brian M and et al. Metabolic Trapping as a Principle of Radiopharmaceutical Design: Some Factors Responsible for the Biodistribution of [18F] 2-Deoxy-2-Fluoro-D-Glucose The Journal of Nuclear Medicine 19:1154-1161,1978
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