Metallothionein-3

Metallothionein 3
PDB rendering based on 2f5h.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2F5H​, 2FJ4​, 2FJ5​
Identifiers
Symbols	MT3 ; GIF; GIFB; GRIF; ZnMT3
External IDs	OMIM: 139255 MGI: 97173 HomoloGene: 136800 ChEMBL: 1250357 GeneCards: MT3 Gene
Gene ontology Molecular function • copper ion binding • protein binding • drug binding • zinc ion binding • antioxidant activity • protein kinase activator activity • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • cadmium ion binding Cellular component • extracellular space • intracellular • cytoplasm • mitochondrial outer membrane • rough endoplasmic reticulum • ribosome • microtubule • plasma membrane • synaptic vesicle • postsynaptic density • inclusion body • axon • dendritic spine • perinuclear region of cytoplasm • astrocyte end-foot Biological process • protein import into nucleus, translocation • response to hypoxia • positive regulation of protein phosphorylation • energy reserve metabolic process • cholesterol catabolic process • zinc II ion transport • cellular metal ion homeostasis • cellular zinc ion homeostasis • brain development • cell proliferation • negative regulation of autophagy • positive regulation of gene expression • positive regulation of necrotic cell death • positive regulation of cell death • astrocyte development • histone modification • removal of superoxide radicals • negative regulation of cell growth • negative regulation of axon extension • positive regulation of vascular endothelial growth factor receptor signaling pathway • regulation of response to food • activation of protein kinase B activity • leptin-mediated signaling pathway • cellular response to oxidative stress • cellular response to drug • positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress • negative regulation of apoptotic process • positive regulation of catalytic activity • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • protein kinase B signaling • negative regulation of neuron apoptotic process • cellular lipid catabolic process • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • protein stabilization • negative regulation of oxidoreductase activity • zinc ion homeostasis • cadmium ion homeostasis • regulation of protein glycosylation • negative regulation of necrotic cell death • ERK1 and ERK2 cascade • positive regulation of ERK1 and ERK2 cascade • cellular response to cadmium ion • cellular response to hypoxia • cellular response to nitric oxide • positive regulation of lysosomal membrane permeability • negative regulation of cysteine-type endopeptidase activity • negative regulation of hydrogen peroxide catabolic process • positive regulation of oxygen metabolic process • negative regulation of reactive oxygen species metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4504	17751
Ensembl	ENSG00000087250	ENSMUSG00000031760
UniProt	P25713	P28184
RefSeq (mRNA)	NM_005954	NM_013603
RefSeq (protein)	NP_005945	NP_038631
Location (UCSC)	Chr 16: 56.59 – 56.59 Mb	Chr 8: 94.15 – 94.15 Mb
PubMed search

Metallothionein-3 is a protein that in humans is encoded by the MT3 gene.^[1][2][3]

References

1. Palmiter RD, Findley SD, Whitmore TE, Durnam DM (Jul 1992). "MT-III, a brain-specific member of the metallothionein gene family". Proceedings of the National Academy of Sciences of the United States of America 89 (14): 6333–7. doi:10.1073/pnas.89.14.6333. PMC 49495. PMID 1631128.
2. Felizola SJ, Nakamura Y, Arata Y, Ise K, Satoh F, Rainey WE, Midorikawa S, Suzuki S, Sasano H (Sep 2014). "Metallothionein-3 (MT-3) in the human adrenal cortex and its disorders". Endocrine Pathology 25 (3): 229–235. doi:10.1007/s12022-013-9280-9. PMID 24242700.
3. "Entrez Gene: MT3 metallothionein 3".

Further reading

• Aschner M (Aug 1996). "The functional significance of brain metallothioneins". FASEB Journal 10 (10): 1129–36. PMID 8751715.
• Tsuji S, Kobayashi H, Uchida Y, Ihara Y, Miyatake T (Dec 1992). "Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease". The EMBO Journal 11 (13): 4843–50. PMC 556960. PMID 1464312.
• Uchida Y, Takio K, Titani K, Ihara Y, Tomonaga M (Aug 1991). "The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein". Neuron 7 (2): 337–47. doi:10.1016/0896-6273(91)90272-2. PMID 1873033.
• Hewitt JE, Gordon MM, Taggart RT, Mohandas TK, Alpers DH (Jun 1991). "Human gastric intrinsic factor: characterization of cDNA and genomic clones and localization to human chromosome 11". Genomics 10 (2): 432–40. doi:10.1016/0888-7543(91)90329-D. PMID 2071148.
• Amoureux MC, Wurch T, Pauwels PJ (Sep 1995). "Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes". Biochemical and Biophysical Research Communications 214 (2): 639–45. doi:10.1006/bbrc.1995.2334. PMID 7677777.
• Naruse S, Igarashi S, Furuya T, Kobayashi H, Miyatake T, Tsuji S (Jul 1994). "Structures of the human and mouse growth inhibitory factor-encoding genes". Gene 144 (2): 283–7. doi:10.1016/0378-1119(94)90391-3. PMID 8039715.
• Moffatt P, Séguin C (Jun 1998). "Expression of the gene encoding metallothionein-3 in organs of the reproductive system". DNA and Cell Biology 17 (6): 501–10. doi:10.1089/dna.1998.17.501. PMID 9655243.
• Garrett SH, Sens MA, Shukla D, Nestor S, Somji S, Todd JH, Sens DA (Nov 1999). "Metallothionein isoform 3 expression in the human prostate and cancer-derived cell lines". The Prostate 41 (3): 196–202. doi:10.1002/(SICI)1097-0045(19991101)41:3<196::AID-PROS7>3.0.CO;2-U. PMID 10517878.
• Ye B, Maret W, Vallee BL (Feb 2001). "Zinc metallothionein imported into liver mitochondria modulates respiration". Proceedings of the National Academy of Sciences of the United States of America 98 (5): 2317–22. doi:10.1073/pnas.041619198. PMC 30136. PMID 11226237.
• Kim D, Garrett SH, Sens MA, Somji S, Sens DA (Feb 2002). "Metallothionein isoform 3 and proximal tubule vectorial active transport". Kidney International 61 (2): 464–72. doi:10.1046/j.1523-1755.2002.00153.x. PMID 11849386.
• Palumaa P, Eriste E, Njunkova O, Pokras L, Jörnvall H, Sillard R (May 2002). "Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals noncooperatively". Biochemistry 41 (19): 6158–63. doi:10.1021/bi025664v. PMID 11994011.
• Uchida Y, Gomi F, Masumizu T, Miura Y (Aug 2002). "Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging". The Journal of Biological Chemistry 277 (35): 32353–9. doi:10.1074/jbc.M111263200. PMID 12058024.
• You HJ, Lee KJ, Jeong HG (Jun 2002). "Overexpression of human metallothionein-III prevents hydrogen peroxide-induced oxidative stress in human fibroblasts". FEBS Letters 521 (1-3): 175–9. doi:10.1016/S0014-5793(02)02870-3. PMID 12067712.
• Roschitzki B, Vasák M (Jun 2002). "A distinct Cu(4)-thiolate cluster of human metallothionein-3 is located in the N-terminal domain". Journal of Biological Inorganic Chemistry 7 (6): 611–6. doi:10.1007/s00775-002-0339-1. PMID 12072966.
• Dutta R, Sens DA, Somji S, Sens MA, Garrett SH (Jul 2002). "Metallothionein isoform 3 expression inhibits cell growth and increases drug resistance of PC-3 prostate cancer cells". The Prostate 52 (2): 89–97. doi:10.1002/pros.10097. PMID 12111700.
• Tate DJ, Miceli MV, Newsome DA (Jan 2002). "Expression of metallothionein isoforms in human chorioretinal complex". Current Eye Research 24 (1): 12–25. doi:10.1076/ceyr.24.1.12.5426. PMID 12187490.
• You HJ, Oh DH, Choi CY, Lee DG, Hahm KS, Moon AR, Jeong HG (Oct 2002). "Protective effect of metallothionein-III on DNA damage in response to reactive oxygen species". Biochimica et Biophysica Acta 1573 (1): 33–8. doi:10.1016/s0304-4165(02)00325-2. PMID 12383939.