Metallothionein 1G

Metallothionein 1G
PDB rendering based on 1mhu.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1mhu​, 1mrb​, 1mrt​, 2mhu​
Identifiers
Symbols	MT1G ; MT1; MT1K
External IDs	OMIM: 156353 HomoloGene: 130541 GeneCards: MT1G Gene
Gene ontology Molecular function • protein binding • zinc ion binding Cellular component • nucleus • cytoplasm • perinuclear region of cytoplasm Biological process • monocyte differentiation • cellular response to vascular endothelial growth factor stimulus • monocyte activation • negative regulation of growth • cellular response to cadmium ion • cellular response to copper ion • cellular response to zinc ion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4495	n/a
Ensembl	ENSG00000125144	n/a
UniProt	P13640	n/a
RefSeq (mRNA)	NM_001301267	n/a
RefSeq (protein)	NP_001288196	n/a
Location (UCSC)	Chr 16: 56.67 – 56.67 Mb	n/a
PubMed search		n/a

Metallothionein-1G is a protein that in humans is encoded by the MT1G gene.^[1][2][3]

References

1. Foster R, Jahroudi N, Varshney U, Gedamu L (Sep 1988). "Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals". J Biol Chem 263 (23): 11528–35. PMID 3403543.
2. Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A 81 (17): 5494–8. doi:10.1073/pnas.81.17.5494. PMC 391732. PMID 6089206.
3. "Entrez Gene: MT1G metallothionein 1G".

Further reading

• West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13.". Genomics 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.
• Gedamu L, Varshney U, Jahroudi N, et al. (1987). "Structure and expression of the human metallothionein genes.". Experientia Suppl. 52: 361–72. doi:10.1007/978-3-0348-6784-9_34. PMID 2444457.
• Varshney U, Jahroudi N, Foster R, Gedamu L (1987). "Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids.". Mol. Cell. Biol. 6 (1): 26–37. PMC 367480. PMID 3023827.
• Pauwels M, van Weyenbergh J, Soumillion A, et al. (1994). "Induction by zinc of specific metallothionein isoforms in human monocytes.". Eur. J. Biochem. 220 (1): 105–10. doi:10.1111/j.1432-1033.1994.tb18603.x. PMID 8119276.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
• Huang Y, de la Chapelle A, Pellegata NS (2003). "Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma.". Int. J. Cancer 104 (6): 735–44. doi:10.1002/ijc.11006. PMID 12640681.
• Cui YP, Wang JB, Zhang XY, et al. (2003). "Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene.". World J. Gastroenterol. 9 (9): 1892–6. PMID 12970870.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors.". Oncogene 24 (13): 2204–17. doi:10.1038/sj.onc.1208206. PMID 15735762.
• Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.". Toxicology and industrial health 19 (7-10): 157–63. doi:10.1191/0748233703th185oa. PMID 15747776.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.