Metanephrines

Noradrenaline breakdown, with normetanephrine visible at upper left.

The metanephrines group of molecules consist of metanephrine and normetanephrine.^[1]

An article in the Journal of the American Medical Association, 2002, indicated that the measurement of plasma free levels of metanephrines is the best tool in the diagnosis of pheochromocytoma, an adrenal medullary neoplasm.^[2]

References

↑ "Plasma Free Metanephrines". American Association for Clinical Chemistry. Last reviewed on February 23, 2012. Last modified on February 26, 2013. Check date values in: |date= (help)
↑ Lenders J, Pacak K, Walther M, Linehan W, Mannelli M, Friberg P, Keiser H, Goldstein D, Eisenhofer G (2002). "Biochemical diagnosis of pheochromocytoma: which test is best?". JAMA 287 (11): 1427–34. doi:10.1001/jama.287.11.1427. PMID 11903030. Free full text with registration

Neurotransmitter metabolic intermediates

catecholamines

Anabolism
(tyrosine→epinephrine)

Tyrosine → Levodopa → Dopamine → Norepinephrine → Epinephrine

Catabolism/
metabolites

dopamine:	DOPAL DOPAC MOPET Hydroxytyrosol 3-Methoxytyramine Homovanillic acid

norepinephrine:	3,4-Dihydroxymandelic acid Normetanephrine Vanillylmandelic acid 3-Methoxy-4-hydroxyphenylglycol Dihydroxyphenylethylene glycol

epinephrine:	Metanephrine

tryptophan→serotonin

anabolism:	5-Hydroxytryptophan

catabolism:	5-Hydroxyindoleacetic acid

serotonin→melatonin

Normelatonin

This article is issued from Wikipedia - version of the Sunday, June 28, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.