Methiodide

In organic chemistry, a methiodide is a chemical derivative produced by the reaction of a compound with methyl iodide. Methiodides may be formed through the methylation of amines:

R₃N + CH₃I → (CH₃)R₃N⁺I⁻

Methiodides are generally prepared to alter chemical or pharmacological properties. Examples include:

• Cocaine methiodide, a charged cocaine analog which cannot pass the blood brain barrier and enter the brain^[1]
• Bicuculline methiodide, a water-soluble form of bicuculline

References

1. Hill ER, Tian J, Tilley MR, Zhu MX, Gu HH (2009). Manzoni, Olivier Jacques, ed. "Potencies of Cocaine Methiodide on Major Cocaine Targets in Mice". PLoS ONE 4 (10): e7578. Bibcode:2009PLoSO...4.7578H. doi:10.1371/journal.pone.0007578. PMC 2762027. PMID 19855831.