Methylamine dehydrogenase (amicyanin)

Methylamine dehydrogenase (amicyanin)
Identifiers
EC number 1.4.9.1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Methylamine dehydrogenase (amicyanin) (EC 1.4.9.1, amine dehydrogenase, primary-amine dehydrogenase) is an enzyme with systematic name methylamine:amicyanin oxidoreductase (deaminating).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

methylamine + H2O + amicyanin \rightleftharpoons formaldehyde + ammonia + reduced amicyanin

This enzyme contains tryptophan tryptophylquinone (TTQ) cofactor.

References

  1. De Beer, R., Duine, J.A., Frank, J., Jr. and Large, P.J. (1980). "The prosthetic group of methylamine dehydrogenase from Pseudomonas AM1: evidence for a quinone structure". Biochim. Biophys. Acta 622 (2): 370–374. doi:10.1016/0005-2795(80)90050-1. PMID 6246962.
  2. Eady, R.R. and Large, P.J. (1968). "Purification and properties of an amine dehydrogenase from Pseudomonas AM1 and its role in growth on methylamine". Biochem. J. 106 (1): 245–255. PMC 1198491. PMID 4388687.
  3. Eady, R.R. and Large, P.J. (1971). "Microbial oxidation of amines. Spectral and kinetic properties of the primary amine dehydrogenase of Pseudomonas AM1". Biochem. J. 123 (5): 757–771. PMC 1177077. PMID 5124384.
  4. Cavalieri, C., Biermann, N., Vlasie, M.D., Einsle, O., Merli, A., Ferrari, D., Rossi, G.L. and Ubbink, M. (2008). "Structural comparison of crystal and solution states of the 138 kDa complex of methylamine dehydrogenase and amicyanin from Paracoccus versutus". Biochemistry 47 (25): 6560–6570. doi:10.1021/bi7023749. PMID 18512962.
  5. Meschi, F., Wiertz, F., Klauss, L., Cavalieri, C., Blok, A., Ludwig, B., Heering, H.A., Merli, A., Rossi, G.L. and Ubbink, M. (2010). "Amicyanin transfers electrons from methylamine dehydrogenase to cytochrome c-551i via a ping-pong mechanism, not a ternary complex". J. Am. Chem. Soc. 132 (41): 14537–14545. doi:10.1021/ja105498m. PMID 20873742.

External links

This article is issued from Wikipedia - version of the Wednesday, March 30, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.