Methylglutamate dehydrogenase

methylglutamate dehydrogenase
Identifiers
EC number	1.5.99.5
CAS number	37217-26-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a methylglutamate dehydrogenase (EC 1.5.99.5) is an enzyme that catalyzes the chemical reaction

N-methyl-L-glutamate + acceptor + H₂O $\rightleftharpoons$ L-glutamate + formaldehyde + reduced acceptor

The 3 substrates of this enzyme are N-methyl-L-glutamate, acceptor, and H₂O, whereas its 3 products are L-glutamate, formaldehyde, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is N-methyl-L-glutamate:acceptor oxidoreductase (demethylating). Other names in common use include N-methylglutamate dehydrogenase, and N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating). This enzyme participates in methane metabolism.

References

• Hersh LB, Stark MJ, Worthen S, Fiero MK (1972). "N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme". Arch. Biochem. Biophys. 150 (1): 219–26. doi:10.1016/0003-9861(72)90029-X. PMID 5028076.