Methylornithine synthase

Methylornithine synthase (EC 5.4.99.58, PylB) is an enzyme with systematic name L-lysine carboxy-aminomethylmutase.^[1]^[2] This enzyme catalyses the conversion of L-lysine into (3R)-3-methyl-D-ornithine.

The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical enzymes.

References

↑ Gaston, M.A., Zhang, L., Green-Church, K.B. and Krzycki, J.A. (2011). "The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine". Nature 471: 647–650. doi:10.1038/nature09918. PMC 3070376. PMID 21455182.
↑ Quitterer, F., List, A., Eisenreich, W., Bacher, A. and Groll, M. (2012). "Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis". Angew. Chem. Int. Ed. Engl. 51 (6): 1339–1342. doi:10.1002/anie.201106765. PMID 22095926.

External links

Methylornithine synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Isomerase: mutases (EC 5.4)

5.4.1 Acyl Groups	Lysolecithin acylmutase Precorrin-8X methylmutase

5.4.2 Phosphomutases	Phosphoglycerate mutase Bisphosphoglycerate mutase Phosphoglucomutase Phosphomannomutase PMM1 PMM2

5.4.99 Other groups	Methylmalonyl-CoA mutase Lanosterol synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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