Methylphosphonate synthase

Methylphosphonate synthase (EC 1.13.11.73, mpnS (gene)) is an enzyme with systematic name 2-hydroxyethylphosphonate:O₂ 1,2-oxidoreductase (methylphosphonate forming).^[1] This enzyme catalyses the following chemical reaction

2-hydroxyethylphosphonate + O₂

\rightleftharpoons

methylphosphonate + HCO³⁻

Methylphosphonate synthase is isolated from the marine archaeon Nitrosopumilus maritimus.

References

↑ Metcalf, W.W., Griffin, B.M., Cicchillo, R.M., Gao, J., Janga, S.C., Cooke, H.A., Circello, B.T., Evans, B.S., Martens-Habbena, W., Stahl, D.A. and van der Donk, W.A. (2012). "Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean". Science 337 (6098): 1104–1107. doi:10.1126/science.1219875. PMC 3466329. PMID 22936780.

External links

Methylphosphonate synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: monooxygenases (EC 1.13)

1.13.11: two atoms of oxygen	lipoxygenase: Arachidonate 5-lipoxygenase Arachidonate 12-lipoxygenase/ALOX12 Arachidonate 8-lipoxygenase Arachidonate 15-lipoxygenase/ALOX15 Linoleate 11-lipoxygenase other dioxygenase: Catechol dioxygenase Homogentisate 1,2-dioxygenase Cysteine dioxygenase 4-Hydroxyphenylpyruvate dioxygenase Indoleamine 2,3-dioxygenase Chlorite dismutase

1.13.12: one atom of oxygen	Firefly luciferase

1.13.99: other	Inositol oxygenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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