Methionine transaminase

Methionine transaminase (EC 2.6.1.88, methionine-oxo-acid transaminase) is an enzyme with systematic name L-methionine:2-oxo-acid aminotransferase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

L-methionine + 2-oxo carboxylate

\rightleftharpoons

2-oxo-4-methylthiobutanoate + L-amino acid

The enzyme is most active with L-methionine.

References

↑ Heilbronn, J., Wilson, J. and Berger, B.J. (1999). "Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae". J. Bacteriol. 181: 1739–1747. PMID 10074065.
↑ Dolzan, M., Johansson, K., Roig-Zamboni, V., Campanacci, V., Tegoni, M., Schneider, G. and Cambillau, C. (2004). "Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function". FEBS Lett. 571: 141–146. doi:10.1016/j.febslet.2004.06.075. PMID 15280032.
↑ Schuster, J., Knill, T., Reichelt, M., Gershenzon, J. and Binder, S. (2006). "Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis". Plant Cell 18: 2664–2679. doi:10.1105/tpc.105.039339. PMID 17056707.

External links

Methionine transaminase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: nitrogenous groups (EC 2.6)

2.6.1: Transaminases	Aspartate transaminase GOT1 GOT2 Alanine transaminase GABA transaminase Tyrosine aminotransferase Ornithine aminotransferase Branched chain aminotransferase Alanine—glyoxylate transaminase AGXT

2.6.3: Oximinotransferases	Oximinotransferase

2.6.99: Other	Pyridoxine 5'-phosphate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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