MIR941-1

MicroRNA 941-1
Identifiers
Symbols	MIR941-1 ; MIRN941-1; mir-941-1
External IDs	GeneCards: MIR941-1 Gene
Gene ontology
Orthologs
Species	Human	Mouse
Entrez	100126329	n/a
Ensembl	ENSG00000215946	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr 20: 63.92 – 63.92 Mb	n/a
PubMed search		n/a

MicroRNA 941-1 is a human specific microRNA that is encoded by the MIR941-1 gene.^[1]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.^[1]

Evolution

The miR-941 gene is only found in humans where it first appeared between one and six million years ago. Its copy number and binding sites have decreased with migration out of Africa. miR-941 regulates genes involved in cellular differentiation and neurotransmitter signalling.^[2]

References

1. "Entrez Gene: MicroRNA 941-1".
2. Hu HY, He L, Fominykh K, Yan Z, Guo S, Zhang X, Taylor MS, Tang L, Li J, Liu J, Wang W, Yu H, Khaitovich P (October 2012). "Evolution of the human-specific microRNA miR-941". Nat Commun 3: 1145. doi:10.1038/ncomms2146. PMC 3493648. PMID 23093182.