Michael M. Meguid

Michael M. Meguid, MD, Ph.D.
Michael M. Meguid, M.D., Ph.D.
Born Egypt
Residence Syracuse, New York
Fields obesity, neuroscience, nutrition, biochemistry
Institutions Upstate Medical University, The State University of New York (SUNY)
Alma mater University of London (M.D., 1968), Harvard Medical School (1972) and Massachusetts Institute of Technology (Ph.D., 1981)
Known for
  • Co-founder Breast Surgery Program, Upstate Medical University
  • Editor-in-Chief, Nutrition: The International Journal of Applied and Basic Nutrition Sciences[1]
  • Editor, [The Proceedings],[2] [The International Academy of Perinatal and Prenatal Programming] [3]
Notable awards

Michael M. Meguid, MD, PhD [7] is Professor Surgery Emeritus at Upstate Medical University [8] (The State University of New York), Syracuse, New York.

Biography

Born in Egypt, Michael (Marwan) Meguid spent his childhood in Egypt, Germany, and then England. There he attended University College London (UCL) and University College Hospital Medical School, graduating with his MB BS degree in 1968. For the next two years he was an Anatomy Prosector at UCL, while he successfully completed Part 1 of the Fellowship of the Royal College of Surgeons (FRCS), London qualification. From 1970 until 1976 he did his Surgical Residency at Peter Bent Brigham Hospital, Children’s Hospital; the Joslin Clinic, Harvard Medical School; and at Boston University Hospital, Boston, Massachusetts. It was at Boston University Hospital (now Boston Medical Center[9] that he began his surgical career in Surgical Oncology and Clinical Nutrition, as Assistant Professor. Concomitantly, from 1978 until 1982 he was a graduate student in the Department of Human Nutrition, Massachusetts Institute of Technology (MIT, Cambridge, Massachusetts, earning a PhD in Nutritional Biochemistry.

Over the next five years (1979–1984) he was Associate Surgeon at City of Hope National Medical Center, Duarte, California; UCLA Medical School; and the West Los Angeles VA Medical Center. He was founder and director of the Department of Nutrition, in the Division of Surgery, at the City of Hope. From there he was recruited to a tenured professor position at the Department of Surgery, University Hospital, Upstate Medical University, and the Syracuse VA Hospital, New York. He has been Professor of Surgery; Vice-Chair for Surgical Research; Director of Surgical Metabolism and Nutrition Laboratory, Neuroscience-Physiology Graduate Program (NIH and NGO funded continuously from 1983 through 2011), where he trained 42 graduate students and fellows; and Director of Nutritional Support Services at both hospitals. He was also the director of the Institutional Review Board at Syracuse VA Medical Center. He started in 1983 "Nutrition: The International Journal of Applied and Basic Nutritional Sciences"[10] and in 2010 co-founded "The International Academy of Perinatal and Prenatal Programming" [3] with its open access e-journal "The Proceedings".[2]

Research projects

Recognitions

Nutrition and the Chandra scientific misconduct case

When Michael Meguid, as Editor-in-Chief of Nutrition, retracted in 2005 a paper by Ranjit Kumar Chandra titled “Effect of vitamin and trace-element supplementation on cognitive function in elderly subjects,”[15] Chandra’s filed suit. A decade of discussion about scientific misconduct followed, with the Chandra case being mentioned in 90-plus articles. In February 2016 Chandra was found guilty of misconduct. The Lancet, at this point, retracted the study they had published in 1992.

The paper had been published in 2001. On reading the article, Seth Roberts, Statistics Editor for Nutrition, queried Chandra about his results “because the effect of supplementation seemed too large” and “some results were impossible.” Specifically, he observed that three of the standard errors in Table II of the paper were more than the maximum possible.[16]

Unsatisfied by the response from Chandra, Roberts consulted with Professor Kenneth Carpenter of Berkley and with Michael M. Meguid, who consulted in turn with his Regional Editors, with the British Medical Journal, and with colleagues at University of Edinburgh. One of the latter, Susan Shenkin, wrote a Letter to the Editor of Nutrition, stating that “We were surprised to see the Mini-Mental State Examination (MMSE) score in this healthy group increasing from a mean of 18 (±3) to 28 (±4) in the supplement group (Table II). A MMSE score of less than 26 would conventionally be classified as indicative of mild cognitive impairment, and one less than 22 would be indicative of significant cognitive impairment. Therefore, some of this group must have been demented according to conventional criteria, but Chandra stated that “none suffered from any form of psychiatric illness or dementia” (p. 709).[17] Chandra responded that there had been “a typographical error in the legends to the tables.”[18]

It was in 1993 that Chandra’s work had first been openly questioned, after publication in 1992 in The Lancet of a study on improvement of older people’s memory and thinking after taking a nutritional supplement. The excitement around this article resulted in his being awarded the 125th Anniversary of the Confederation of Canada Medal. In 1994 Chandra’s research nurse reported suspected data falsification to Chandra’s employer, Memorial University of Newfoundland, which carried out investigations. A second investigation in 1995 concluded that Chandra had committed scientific misconduct, but the findings were not made public. In 1997 Health Canada was asked to look into Chandra’s infant nutrition studies but didn’t.[19]

Chandra submitted to the British Medical Journal in 2001 a follow-up to the 1992 Lancet study, which was rejected. He then resubmitted the rejected paper to Nutrition, where it was accepted by this fledgling journal after peer review in 2001. At the same time, the BMJ was raising concerns with Memorial over Chandra’s study. Memorial responded to the British Medical Journal that there was no case.

Scientific publication

Scopus[20] scientific publication data for Michael M. Meguid as of January 2011:

Selected Examples: For these and additional works by Michael M. Meguid and colleagues, refer to PubMed.[21]

  1. Asakawa A, Inui A, Fujimiya M, Sakamaki R, Shinfuku N, Ueta Y, Meguid MM, Kasuga M. Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. 2005, Gut 54(1):18–24.
  2. Giner M, Laviano A, Meguid MM, Gleason JR. In 1995 a correlation between malnutrition and poor outcome in critically ill patients still exists. 1996, Nutrition 12(1):23–29.
  3. Meguid MM, Fetissov SO, Varma M, Sato T, Zhang L, Laviano A, Rossi-Fanelli, F. Hypothalamic dopamine and serotonin in the regulation of food intake. 2000, Nutrition 16(10):843–857.
  4. Meguid MM, Loebl WY. Megaloblastic anemia associated with the oral contraceptive pill. 1974, Postgrad Med 50:470-472.
  5. Boateng, AA, Sriram K, Meguid MM, Crook M. Refeeding Syndrome: Treatment Considerations based on Collective Analysis of Literature Case Reports. Nutrition 2010, 26(12):26.
  6. Meguid, MM, Goncalves CG. Message to surgeons: the expected norm in elective complex GI cancer surgery is use of perioperative immunonutritional therapy that also saves hospital costs! 2009, Ann Surg 2493(3):64-365.
  7. Guijarro A, Osei-Hyiaman D, Harvey-White J, Kunos G, Suzuki S, Nadtochiy S, Brookes PS, Meguid MM. Sustained Weight Loss after Roux-en-Y Gastric Bypass is characterized by Down Regulation of Endocannabinoids and Mitochondrial Function. 2008, Ann Surg 247(5):779-790.
  8. Laviano A, Meguid MM, Inui A, Muscaritoli M, Rossi-Fanelli F. Review: Therapy insight: cancer anorecia-cachexia syndrome- when all you can eat is yourself. 2005, Nature Clinical Practice, Oncology 2:1-8.
  9. Makarenko IG, Meguid MM, Gatto L, Chen C, Ramos EJ, Goncalves CG, Ugrumov MV. Normalization of hypothalamic serotonin (5-HT1B) receptor and NPY in cancer anorexia after tumor resection: An Immunocytochemical Study. 2005, Neurosci Lett 383:322-7.
  10. Xu Y, Ramos EJB, Middleton F, Romanova IV, Quinn R, Chen C, Das UN, Inui A, Meguid MM. Gene expression profiles post Roux-en-Y Gastric Bypass. 2004, Surgery 136:246-52.
  11. Middleton F, Ramos EJB, Xu Y, Diab H, Zhao X, Meguid MM. Application of genomic technologies: DNA-Microarrays and metabolic profiling of obesity in the hypothalamus and subcutaneous fat. 2004, Nutrition 20(1):14-25.
  12. Fettisov S, Meguid MM, Sato T and Zhang L-H. Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats. 2002, Amer J Physiol: Reg Int & Compar Physiolol 283:R905-R910.
  13. Sato T, Meguid MM, Fetissov SO, Chen C, Zhang L. Hypothalamic dopaminergic receptor expressions in anorexia of tumor bearing rats. 2001,Am J Physiol Regulatory Integrative Comp Physiol 281:R1907-R1916.

References

  1. "Nutrition". Elsevier. Retrieved 2011-01-30.
  2. 1 2 "The Proceedings". Prenatalprogramming.org. 2011-01-01. Retrieved 2011-01-30.
  3. 1 2 "Highlights". Prenatalprogramming.org. Retrieved 2011-01-30.
  4. 1 2 "AMA - About the American Medical Association (AMA) Awards Program". Ama-assn.org. Retrieved 2011-01-30.
  5. 1 2 http://www.aacc.org/SiteCollectionDocuments/Master%20Newsletter/Nutrition_Newsletter_Archives/Fall2010.pdf
  6. 1 2 "The European Society for Clinical Nutrition and Metabolism". ESPEN. 2011-01-01. Retrieved 2011-01-30.
  7. "Michael Meguid:Surgery:SUNY Upstate Medical University". Upstate.edu. Retrieved 2011-01-30.
  8. "SUNY Upstate Medical University". Upstate.edu. 2011-01-20. Retrieved 2011-01-30.
  9. "Boston Medical Center | Boston Hospital, Academic Medical Center | Exceptional Care without Exception". Bmc.org. Retrieved 2011-01-30.
  10. "Elsevier Editorial SystemTM". Ees.elsevier.com. Retrieved 2011-01-30.
  11. "International Behavioral Neuroscience Society". Ibnshomepage.org. Retrieved 2011-01-30.
  12. "Editorial introductions : Current Opinion in Clinical Nutrition & Metabolic Care". Journals.lww.com. 2006-10-09. doi:10.1097/MCO.0b013e32832d3ed6. Retrieved 2011-01-30.
  13. "NAASO's Newsletter". Obesity. Retrieved 2011-01-30.
  14. "ACS FOUNDATION | Surgery in the 21st Century". Facs.org. Retrieved 2011-01-30.
  15. Susan D. Shenkin, Martha C. Whiteman, Alison Pattie, Ian J. Deary. (2002). "Supplementation and the Elderly: Dramatic Results?". Nutrition. pp. 364–365. Retrieved 2016-03-08.
  16. http://www.sciencedirect.com/science/article/pii/S089990070300025X. Retrieved 2016-03-08. Missing or empty |title= (help)
  17. (PDF) http://media.sethroberts.net/chandra/Shenkin_letter_in_Nutrition_and_Chandra%27s_reply.pdf. Retrieved 2016-03-08. Missing or empty |title= (help)
  18. (PDF) http://media.sethroberts.net/chandra/Shenkin_letter_in_Nutrition_and_Chandra%27s_reply.pdf. Retrieved 2016-03-08. Missing or empty |title= (help)
  19. http://www.bmj.com/bmj/section-pdf/908205/0. Retrieved 2016-03-08. Missing or empty |title= (help)
  20. http://www.scopus.com/authid/detail.url?origin=resultslist&authorId=17735527900
  21. http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=PureSearch&db=pubmed&term=meguid%20mm[Author]
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