Molybdenum cofactor sulfurtransferase

Molybdenum cofactor sulfurtransferase (EC 2.8.1.9, molybdenum cofactor sulfurase, ABA3, HMCS, MoCo sulfurase, MoCo sulfurtransferase) is an enzyme with systematic name L-cysteine:molybdenum cofactor sulfurtransferase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

molybdenum cofactor + L-cysteine + 2 H⁺

\rightleftharpoons

thio-molybdenum cofactor + L-alanine + H₂O

This enzyme contains pyridoxal phosphate.

References

↑ Bittner, F., Oreb, M. and Mendel, R.R. (2001). "ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana". J. Biol. Chem. 276: 40381–40384. doi:10.1074/jbc.c100472200. PMID 11553608.
↑ Heidenreich, T., Wollers, S., Mendel, R.R. and Bittner, F. (2005). "Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration". J. Biol. Chem. 280: 4213–4218. doi:10.1074/jbc.m411195200. PMID 15561708.
↑ Wollers, S., Heidenreich, T., Zarepour, M., Zachmann, D., Kraft, C., Zhao, Y., Mendel, R.R. and Bittner, F. (2008). "Binding of sulfurated molybdenum cofactor to the C-terminal domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration". J. Biol. Chem. 283: 9642–9650. doi:10.1074/jbc.m708549200. PMID 18258600.

External links

Molybdenum cofactor sulfurtransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: sulfur-containing group (EC 2.8)

2.8.1: Sulfurtransferases	Thiosulfate sulfurtransferase Rhodanese 3-mercaptopyruvate sulfurtransferase thiosulfate—thiol sulfurtransferase tRNA sulfurtransferase thiosulfate—dithiol sulfurtransferase biotin synthase cysteine desulfurase

2.8.2: Sulfotransferases	Alcohol sulfotransferase Tyrosylprotein sulfotransferase Aryl sulfotransferase

2.8.3: CoA-transferases	Propionate CoA-transferase

2.8.4: Alkylthio	Coenzyme-B sulfoethylthiotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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