Molybdopterin molybdotransferase

Molybdopterin molybdotransferase (EC 2.10.1.1, MoeA, Cnx1) is an enzyme with systematic name adenylyl-molybdopterin:molybdate molybdate transferase (AMP-forming).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

adenylyl-molybdopterin + molybdate

\rightleftharpoons

molybdenum cofactor + AMP

Catalyses the insertion of molybdenum into the ene-dithiol group of molybdopterin.

References

↑ Nichols, J.D. and Rajagopalan, K.V. (2005). "In vitro molybdenum ligation to molybdopterin using purified components". J. Biol. Chem. 280: 7817–7822. doi:10.1074/jbc.M413783200. PMID 15632135.
↑ Nichols, J.D., Xiang, S., Schindelin, H. and Rajagopalan, K.V. (2007). "Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft". Biochemistry 46 (1): 78–86. doi:10.1021/bi061551q. PMID 17198377.
↑ Llamas, A., Otte, T., Multhaup, G., Mendel, R.R. and Schwarz, G. (2006). "The Mechanism of nucleotide-assisted molybdenum insertion into molybdopterin. A novel route toward metal cofactor assembly". J. Biol. Chem. 281 (27): 18343–18350. doi:10.1074/jbc.M601415200. PMID 16636046.

External links

Molybdopterin molybdotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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