Multispectral optoacoustic tomography

Multispectral optoacoustic tomography (MSOT) is a technique for whole-body imaging of bio chemical markers in small animals.[1] For example fly pupae and zebrafish.[2] and mice organs.[3]

"MSOT illuminates tissue with light pulses at multiple wavelengths and detects the acoustic waves generated by the thermoelastic expansion of the environment surrounding absorbing molecules."[4]

Possible use for biopsy-free detection of lymph node metastasis

MSOT can detect through 5cm of tissue and it has been evaluated on 500 removed lymph nodes to check for melanin as a sign of melanoma metastasis.[5]

See also

References

  1. ↑ "Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging". 2009.
  2. ↑ "Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo". 2009.
  3. ↑ "Fast Multispectral Optoacoustic Tomography (MSOT) for Dynamic Imaging of Pharmacokinetics and Biodistribution in Multiple Organs". 2012.
  4. ↑ "Multispectral Opto-acoustic Tomography (MSOT) of the Brain and Glioblastoma Characterization". 2012.
  5. ↑ "Biopsy-Free Detection of Melanoma Metastasis". December 17, 2015.Stoffels et a. "Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging". Science Translational Medicine 09 Dec 2015: Vol. 7, Issue 317, pp. 317ra199. doi:10.1126/scitranslmed.aad1278. line feed character in |journal= at position 45 (help)
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