Multisynthetase complex auxiliary component p38

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4DPG​
Identifiers
Symbols	AIMP2 ; JTV-1; JTV1; P38; PRO0992
External IDs	OMIM: 600859 MGI: 2385237 HomoloGene: 4594 GeneCards: AIMP2 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • cytosol • membrane Biological process • tRNA aminoacylation for protein translation • apoptotic process • negative regulation of cell proliferation • gene expression • positive regulation of protein ubiquitination • Type II pneumocyte differentiation • positive regulation of neuron death Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7965	231872
Ensembl	ENSG00000106305	ENSMUSG00000029610
UniProt	Q13155	Q8R010
RefSeq (mRNA)	NM_006303	NM_001172146
RefSeq (protein)	NP_006294	NP_001165617
Location (UCSC)	Chr 7: 6.01 – 6.02 Mb	Chr 5: 143.9 – 143.91 Mb
PubMed search

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 is an enzyme that in humans is encoded by the AIMP2 gene.^[1][2][3]

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown.^[3]

Interactions

Multisynthetase complex auxiliary component p38 has been shown to interact with Parkin (ligase),^[4] P53^[2] and KARS.^[5][6]

References

1. Nicolaides NC, Kinzler KW, Vogelstein B (Aug 1996). "Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene". Genomics 29 (2): 329–34. doi:10.1006/geno.1995.9997. PMID 8666379.
2. Han JM, Park BJ, Park SG, Oh YS, Choi SJ, Lee SW, Hwang SK, Chang SH, Cho MH, Kim S (Aug 2008). "AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53". Proc Natl Acad Sci U S A 105 (32): 11206–11. doi:10.1073/pnas.0800297105. PMC 2516205. PMID 18695251.
3. "Entrez Gene: JTV1 JTV1 gene".
4. Corti, Olga; Hampe Cornelia, Koutnikova Hana, Darios Frédéric, Jacquier Sandrine, Prigent Annick, Robinson Jean-Charles, Pradier Laurent, Ruberg Merle, Mirande Marc, Hirsch Etienne, Rooney Thomas, Fournier Alain, Brice Alexis (Jun 2003). "The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration". Hum. Mol. Genet. (England) 12 (12): 1427–37. doi:10.1093/hmg/ddg159. ISSN 0964-6906. PMID 12783850. Cite uses deprecated parameter |coauthors= (help)
5. Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Cite uses deprecated parameter |coauthors= (help)
6. Quevillon, S; Robinson J C; Berthonneau E; Siatecka M; Mirande M (Jan 1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". J. Mol. Biol. (ENGLAND) 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. ISSN 0022-2836. PMID 9878398.

Further reading

• Park SG, Ewalt KL, Kim S (2005). "Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers.". Trends Biochem. Sci. 30 (10): 569–74. doi:10.1016/j.tibs.2005.08.004. PMID 16125937.
• Raszewski W (1978). "Protective action of series of new mono-pyridinium salts and their effect on "aging" of acetylcholine esterase inhibited by fluostigmine.". Polish journal of pharmacology and pharmacy 29 (6): 603–7. PMID 600859.
• Norcum MT (1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents.". J. Biol. Chem. 266 (23): 15398–405. PMID 1651330.
• Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.". J. Mol. Biol. 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. PMID 9878398.
• Kang J, Kim T, Ko YG, et al. (2000). "Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases.". J. Biol. Chem. 275 (41): 31682–8. doi:10.1074/jbc.M909965199. PMID 10913161.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Ahn HC, Kim S, Lee BJ (2003). "Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43.". FEBS Lett. 542 (1–3): 119–24. doi:10.1016/S0014-5793(03)00362-4. PMID 12729910.
• Corti O, Hampe C, Koutnikova H, et al. (2004). "The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.". Hum. Mol. Genet. 12 (12): 1427–37. doi:10.1093/hmg/ddg159. PMID 12783850.
• Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation.". Nat. Genet. 34 (3): 330–6. doi:10.1038/ng1182. PMID 12819782.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Sampath P, Mazumder B, Seshadri V, et al. (2004). "Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation.". Cell 119 (2): 195–208. doi:10.1016/j.cell.2004.09.030. PMID 15479637.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.